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(Deferasirox) was approved by the FDA in November 2005 for use in patients 2 years and older with chronic iron overload caused by blood transfusions. In December 2012, Deferasirox was approved by the European Commission for the treatment of chronic iron overload in patients aged 10 years and above with non-transfusion-dependent thalassemia (NTDT) syndrome who require chelation therapy due to contraindications or insufficiency of deferoxamine mesylate therapy. On January 23, 2013, the FDA approved a new indication for Deferasirox (Deferasirox) for the treatment of chronic iron overload in patients aged 10 years and older with non-transfusion-dependent thalassemia (NTDT). When should I take Deferasirox? Let's take a look.

Starting dose: 1. The recommended starting dose of Deferasirox is 20 mg/kg. 2. For patients who receive monthly transfusions of more than 14 mL/kg of packed red blood cells (i.e., more than 4 units/month for adults) and need to reduce excessive iron exposure, a starting dose of 30 mg/kg/day may be considered. 3. For patients who receive monthly transfusions of less than 7 mL/kg of packed red blood cells (i.e., less than 2 units/month for adults) and who need to maintain iron balance in the body, a starting dose of 10 mg/kg/day may be considered. 4. For patients who have already responded well to deferoxamine treatment, the initial dose of Enriga may be equivalent to half of the dose of deferoxamine. (For example, a patient receiving deferoxamine 40 mg/kg/day, 5 days per week, or equivalent, may start at 20 mg/kg if switched to Enriga.)

How to take: Deferasirox should be taken on an empty stomach at least 30 minutes before meals, once a day, preferably at the same time every day. Tablets should not be chewed or swallowed whole. (Deferasirox) should not be taken with aluminum-containing antacids. The dosage (mg/kg) needs to be calculated and rounded to the nearest whole tablet. Completely dissolve the tablets in water, apple juice or orange juice (100-200mL) by stirring until a clear suspension is obtained and then drink it. The remaining medicine must be added with a small amount of water, apple juice or orange juice and mixed well before taking. Not recommended for dissolution in carbonated drinks or milk as it can cause foaming and slow dispersion.

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