瑞士诺华的地拉罗司说明书

Instructions for Novartis Switzerland

Generic name: Deferasirox

Product name: Enrig

English name: Deferasirox, Desirox

Manufacturer: Novartis, Switzerland

Time on the market: China in 2010

Indications: For the treatment of chronic iron overload caused by frequent blood transfusions in patients with β-thalassemia aged 2 years and above and chronic iron overload in patients with non-transfusion-dependent thalassemia (NTDT) syndrome aged 10 years and above.

Usage and Dosage: It is recommended for patients with iron accumulation, such as those who require long-term blood transfusion (blood transfusion volume reaches 100ml/kg) and whose serum ferritin exceeds 1000ug/L; corresponding to the body weight, it is initially recommended to take 20mg/kg of deferasole daily. If the serum ferritin index improves, the patient may need to adjust or increase the dose of deferasirox. Generally, the dose will be increased in units of 5 mg/kg or 10 mg/kg, but the total dose should not exceed 30 mg/kg per day.

Deferasirox needs to be taken once daily on an empty stomach, preferably at the same time each day. Do not take it with aluminum-containing antacids or other iron chelation treatments.

Medication for special groups: Pregnant and lactating women and elderly patients should use deferasirox with caution. Children under 6 years old should use with caution. Children under 2 years old should not use it.

Adverse reactions: Common adverse reactions of deferasirox include increased serum creatinine, abdominal pain, nausea, vomiting, diarrhea, proteinuria, irritation, headache, cough, nasopharyngitis, sore throat, influenza, and rash.

Contraindications: Do not use if you are allergic to or allergic to any of the ingredients.

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Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.