Dosage and dosage of dienogest

Endometriosis (EMs) is a common gynecological disease in women caused by endometrial cells growing in abnormal locations. Many international clinical research data show that it can effectively relieve EMs pain, reduce endometriosis lesions, and has good safety and tolerability. Today let’s learn about the usage and dosage of dienogest.

Usage and dosage: Dienogest is taken orally, one tablet a day, without interruption, preferably at the same time every day, with water when necessary. Dienogest can be taken after a meal or on an empty stomach. The tablets must be taken continuously, regardless of whether vaginal bleeding occurs. If you finish taking one box, start taking the next box without interruption. You can start treatment with this product on any day of the menstrual cycle.

Dienogest is a new type of selective progesterone receptor agonist that can inhibit ovarian function and endometrial cell proliferation, thereby reducing the pain associated with EMs and shrinking and shrinking the lesions. Indications for dienogest: Treatment of endometriosis.

In May 2019, dienogest tablets (Weisaning) were launched in China. It is a progesterone specially developed for endometriosis. Due to its unique molecular structure, it can inhibit and transform the endometrium more efficiently than other progestins, so it only requires a smaller dose to significantly inhibit endometriosis lesions and pain. Compared with GnRH-a, dienogest tablets will not increase side effects caused by low estrogen such as bone loss, hot flashes and night sweats, insomnia and irritability. Long-term use will not affect liver and kidney function or increase weight. It has relatively few side effects and is safe for long-term use.

Dienogest tablets are effective on all endometriosis lesions throughout the body. It is currently the only oral endometriosis drug that can be taken orally for a long time, has definite efficacy and has few side effects. The disadvantage is that it needs to be taken orally every day.

Dienogest is a 19-nortestosterone derivative. It does not have androgenic activity, but it has anti-androgenic activity. Its activity is about one-third that of cyproterone acetate. Its binding affinity to the progesterone receptor in the human uterus is only 10% of that of progesterone. Although its affinity to the progesterone receptor is low, it has a strong progesterone effect in the body. Dienogest has no obvious androgenic, mineralocorticoid, or glucocorticoid activity in the body.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.