达那唑有哪些副作用？

Although danazol has significant therapeutic effects, it also has side effects. The following events related to the use of danazol are reported in the drug instructions:

Androgen-like effects include weight gain, acne, and seborrhea. Mild hirsutism, edema, alopecia, and voice changes manifested as hoarseness, sore throat, or unstable or deepened pitch may occur after treatment with danazol and persist after treatment is discontinued. Clitoromegaly is rare.

Other possible endocrine effects are menstrual disturbances including spotting, changes in menstrual cycle timing, and amenorrhea. Although periodic bleeding and ovulation usually

Recovery occurs within 60 to 90 days after discontinuation of danazol therapy, and persistent amenorrhea has occasionally been reported. Flushing, sweating, vaginal dryness and irritation, and breast reduction may reflect reduced estrogen levels. Nervousness and emotional lability have been reported. A modest reduction in spermatogenesis may be evident in males during danazol treatment. Patients receiving long-term treatment may develop abnormalities in semen volume, viscosity, sperm count, and motility.

Hepatic dysfunction, manifested by reversible elevations in serum enzymes and/or jaundice, has been reported in patients taking 400 mg or more of danazol daily. It is recommended that patients receiving danazol be monitored for hepatic dysfunction through laboratory testing and clinical observation. Serious hepatotoxicity including cholestatic jaundice, hepatic fibrosis, and hepatic adenomas have been reported.

Laboratory test abnormalities may occur during treatment with danazol, including CPK, glucose tolerance, glucagon, thyroid-binding globulin, sex hormone-binding globulin, other plasma proteins, lipids, and lipoproteins.

Rare cases of malignant liver tumors have been reported after long-term use.

The following reactions have been reported and a causal relationship with danazol administration has not been confirmed or disproved;

Allergy: urticaria, itching and rarely, nasal congestion;

Central nervous system effects: headache, nervousness and mood lability, dizziness and syncope, depression, fatigue, sleep disturbance, tremor, paresthesias, weakness, visual disturbances and rare benign intracranial hypertension, anxiety, appetite changes, chills and rare convulsions, Guillain-Barre syndrome;

Gastrointestinal: Gastroenteritis, nausea, vomiting, constipation, and rarely pancreatitis and splenomegaly;

Musculoskeletal: Muscle spasms or spasms, or pain, joint pain, joint locking, joint swelling, back, neck, or extremity pain, and rarely carpal tunnel syndrome that may be secondary to fluid retention;

Genitourinary system: hematuria, prolonged amenorrhea after treatment;

Hematology: Increased red blood cell and platelet counts. May cause reversible polycythemia, leukocytosis, or polycythemia. Eosinophilia, leukopenia, and thrombocytopenia were also observed;

Skin: Rash (maculopapular, vesicular, papular, purpuric, petechial), rarely, sun allergy, Stevens-Johnson syndrome and erythema multiforme;

Others: increased insulin requirements, changes in sexual desire, myocardial infarction, palpitations, tachycardia, elevated blood pressure, interstitial pneumonia, and rare cataracts, gum bleeding, fever, pelvic pain, and nipple discharge in diabetic patients.

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