子宫内膜异位症药物达那唑胶囊作用和副作用

Introduction: Danazol capsule is an androgen inhibitory drug with anti-gonadotropin and mild androgenic effects. It is a synthetic steroidal heterocyclic compound. This article mainly talks about the indications, mechanism of action, main effects, side effects and management, precautions and drug interactions of danazol.

Indications

Danazol is mainly used to treat endometriosis. Also indicated for the treatment of fibrocystic breast disease, idiopathic thrombocytopenic purpura, hereditary angioedema, systemic lupus erythematosus, gynecomastia, and precocious puberty.

Mechanism of action

Danazol reduces the production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by inhibiting the release of pituitary gonadotropins. It can also directly inhibit the production of ovarian steroid hormones and act on the estrogen receptor sites of endometrial cells, thereby inhibiting the effectiveness of estrogen.

Main functions

1. Inhibit the pituitary-gonadal axis: Indirectly inhibit the secretion of LH and FSH in the anterior pituitary gland by inhibiting the secretion of GnRH in the hypothalamus.

2. Promote follicle development: It can promote the development and maturity of follicles and stimulate the secretion of estrogen, thereby promoting follicle development.

3. Inducing menstrual cycle: This drug has a weak androgen-like effect and can simulate a small amount of androgen levels produced during the follicular phase of the normal menstrual cycle, thereby inducing the occurrence of menstrual cycles.

4. Improve endometriosis: Because it has a certain anti-inflammatory effect, it has a certain alleviation effect on the pain symptoms caused by endometriosis.

5. Reduce platelet count: Danazol can reduce the production of megakaryocytes, leading to reduced platelet production.

Side effects and management

When using danazol capsules, attention should be paid to possible adverse reactions, such as amenorrhea, breast reduction, muteness, breakthrough uterine bleeding, increased hair and other manifestations of androgenic effects. Less common adverse reactions include hematuria, epistaxis, gum bleeding, abnormal liver function, etc. When using danazol capsules, liver function, kidney function and blood lipid levels should be monitored, and medication should be administered under the guidance of a physician to evaluate possible side effects or interactions with other disease treatments.

Precautions

Athletes should use danazol with caution. Liver function tests should be paid attention to during treatment with danazol. Men need to check semen volume, viscosity, sperm count and motility when taking medication. When women start taking it, they should take contraceptive measures to prevent pregnancy. Pregnant women should not use this drug, and those who become pregnant while taking the drug should terminate their pregnancy. Elderly patients have low physiological functions and should take reduced dosage.

Drug interactions

Danazol may easily develop drug resistance when used together with insulin. When danazol and warfarin are used together, the anticoagulant effect will be enhanced and bleeding may occur easily. Danazol may inhibit the hepatic metabolism of tacrolimus and cyclosporine, possibly resulting in increased concentrations of these drugs in the body. May reduce the body's maintenance requirements for alfacalcidol, so bone density and bone metabolism markers need to be monitored when using these two drugs.

Danazol capsules are a prescription drug and need to be used under the guidance of a doctor. When using danazol capsules, you should strictly follow the doctor's instructions and conduct regular physical examinations to evaluate the effects of the drug and possible adverse reactions.