阿法脱氧核糖核酸酶吸入剂(Pulmozyme)的副作用和处理措施？

The most common adverse reactions of Alfa deoxyribonuclease inhaler (Pulmozyme) include voice changes, pharyngitis, rash, laryngitis, chest pain, conjunctivitis, rhinitis, fever, indigestion, difficulty breathing, etc. Different side effects need to be treated in a targeted manner to relieve uncomfortable symptoms, but if serious side effects occur, you should go to the hospital in time.

Alfa deoxyribonuclease inhaler (Pulmozyme)

It is a recombinant DNA enzyme indicated as a standard treatment for patients with cystic fibrosis (CF) to improve lung function.

Side effects of alfa deoxyribonuclease inhaler

Pulmozyme's main side effects include voice change, pharyngitis, rash, laryngitis, chest pain, conjunctivitis, rhinitis, fever, indigestion, dyspnea, etc. Dyspnea is a more serious side effect.

Treatment measures for side effects of alfa deoxyribonuclease inhaler

1. Pharyngitis: Patients should drink more water to keep their throat moist, relieve throat pain and discomfort, and avoid ingesting irritating foods and drinks, such as chili peppers, alcohol, etc. These foods will irritate the throat and aggravate the original discomfort symptoms. If symptoms persist or worsen, you should immediately stop using alfa deoxyribonuclease inhaler and consult a doctor for diagnosis and treatment.

2. Skin rash: During medication, pay attention to keeping the skin clean, hygienic, and dry, and avoid scratching with your hands to avoid secondary infection. Some anti-allergic drugs, such as chlorpheniramine, loratadine, etc., can also be used under the guidance of a doctor. If the rash is severe, systemic drugs, such as hormones, may be needed.

3. Fever: You can physically cool down by wiping with warm water, applying antipyretic patches, applying ice, etc. If the body temperature rises further, you can use antipyretic drugs such as ibuprofen and acetaminophen as directed by your doctor. After taking the medicine, you should drink more water to promote body metabolism.

4. Indigestion: It is recommended to avoid eating foods that are not easy to digest, avoid overeating, chew slowly, eat regularly and quantitatively, and do not lie down immediately after eating. You can promote intestinal peristalsis and promote food digestion through walking and other methods. You can also use local massage. Appropriate clockwise massage of the abdomen can regulate the gastrointestinal tract and improve digestive function.

Alfa deoxyribonuclease inhalants may cause serious side effects, such as severe adverse reactions in the blood system, difficulty breathing, allergic reactions, etc. If symptoms are severe or continue to worsen, seek medical attention immediately and avoid self-treatment.

alfa deoxyribonuclease inhaler

Nebulized alfa deoxyribonuclease inhalation has previously been shown to increase lung function and reduce exacerbations of respiratory symptoms in cystic fibrosis (CF) patients with moderately to severely reduced lung function. In a one-year study, the number of positive cultures was significantly higher in the untreated group (82%) than in the treated group (72%).

Lung function (FEV1) increased significantly by 7.3% in the treated group compared to 0.9% in the untreated group. Long-term alfa deoxyribonuclease inhaled therapy is beneficial in CF patients without chronic lower respiratory tract infection, reducing the need for antibiotics and improving lung function.

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