盐酸阿考替胺的作用疗效和特殊人群用药详述

Introduction: Acotiamide hydrochloride (Acotiamide) is a new selective acetylcholinesterase (AChE) inhibitor. It is an effective drug for the treatment of functional dyspepsia (FD). It has the effect of improving gastric motility and alleviating the symptoms of indigestion, and has good safety. This article mainly talks about the efficacy, mechanism of action, safety, medication for special groups, medication instructions and storage methods of acotiamide hydrochloride.

Effectiveness

Clinical studies have shown that acotiamide can significantly improve the symptoms of FD patients, such as postprandial fullness, epigastric distension, and early satiety. It reduces symptoms caused by FD by improving gastric motility and emptying ability

Mechanism of action

Acotiamide promotes the release of acetylcholine and inhibits acetylcholinesterase activity by acting on muscarinic receptors on smooth muscle nerve endings, thereby improving the impaired gastric adaptive diastolic function, increasing gastric capacity, promoting gastric antrum contraction, and accelerating gastric emptying.

High safety

Acotiamide hydrochloride has been subjected to a number of clinical studies in Japan, such as breath test, ultrasound test and TQT test. These studies have proven that acotiamide hydrochloride can significantly improve FD symptoms and is highly safe. The improvement effect can still be maintained after stopping the drug, and it is not easy to develop drug resistance after repeated administration.

Drug use in special populations

Elderly patients may have reduced body functions and metabolic capabilities, so special caution is required when using acotiamide hydrochloride. Doctors may adjust the dose or frequency of medication based on the patient's age and overall health. The metabolism of acotiamide hydrochloride may be affected in patients with hepatic impairment. Patients with hepatic and renal insufficiency need to regularly monitor liver function indicators and renal function indicators during the use of acotiamide hydrochloride. There are limited data on the safety and effectiveness of acotiamide hydrochloride in pregnant and lactating women. There are limited data on the safety and effectiveness of acotiamide hydrochloride in children.

Dosage Instructions

Generally, adults take 100 mg (1 tablet) once, 3 times a day, orally before meals. If symptoms do not improve after 1 month of use, discontinuation of use should be considered. If symptoms continue to improve, you should consider discontinuing this drug and be careful not to use it for a long time.

Storage method

The storage method of acotiamide hydrochloride should be carried out in accordance with the instructions on the drug package insert. It usually needs to be stored under specified temperatures and conditions to maintain its stability and effectiveness. They should be stored in an environment below 30°C and protected from light. Drugs usually have specific packaging requirements to maintain the quality and integrity of the drug. Store acotiamide hydrochloride out of the reach of children to prevent accidental ingestion or overdose.

When using acotiamide hydrochloride, doctors should weigh the pros and cons and formulate a personalized medication plan based on the patient's specific situation. Patients should closely monitor their physical condition while using the drug, and seek medical treatment in time if they have any symptoms of discomfort.