日本版的盐酸阿考替胺(Acofide)和莫沙必利的区别有哪些？

Both the Japanese version and Mosapride can promote gastrointestinal motility, but there are certain differences between the two in terms of indications, marketing information, drug prices, different manufacturers, different drug properties, mechanisms of action, dosage, adverse reactions, etc. It is recommended that patients choose their own medication according to their own conditions and under the guidance of a doctor.

Different indications

The Japanese version of acotiamide hydrochloride (Acofide) is suitable for patients with functional dyspepsia, while mosapride can be used not only to treat functional dyspepsia, but also for diabetic gastroparesis, gastroesophageal reflux disease, and gastric dysfunction in patients with partial gastrectomy.

The marketing information is different

In June 2013, acotiamide hydrochloride (Acofide) was approved for marketing in Japan. But as of January 2024, acotiamide hydrochloride (Acofide) has not yet been launched in China.

Mosapride, whose full name is Mosapride Citrate Tablets, has been launched in China and is currently included in medical insurance.

Drug prices are different

The Japanese version of Acofide hydrochloride (Acofide) is about $360 for a box of 100mg*100 tablets. Mosapride is cheap, with a reference price of around $20 for a box.

Different manufacturers

Acofide hydrochloride (Acofide) is the first prokinetic oral drug being developed globally by Zeria Pharmaceutical Co., Ltd. and Astellas Pharma Inc. Acofide hydrochloride (Acofide) is the world's first drug approved for the treatment of functional dyspepsia diagnosed according to the Rome III criteria. Its first approval occurred in Japan. Mosapride is produced by Yabao Pharmaceutical Group Co., Ltd. in China.

Drug properties are different

Acofide hydrochloride (Acofide) is an acetylcholinesterase inhibitor that can enhance the effect of acetylcholine. Mosapride is a selective 5-hydroxytryptamine (5-HT) receptor agonist.

Different mechanisms of action

Acofide hydrochloride (Acofide) can regulate upper gastrointestinal tract motility to relieve abdominal symptoms caused by insufficient motility and delayed gastric emptying. It exerts activity in the stomach by inhibiting muscarinic receptors, resulting in increased acetylcholine release and inhibition of acetylcholinesterase activity. It is used to treat functional digestion. Unlike other undesirable prokinetic drugs, acotiamide hydrochloride (Acofide) has almost no affinity for 5-hydroxytryptamine or dopamine D2 receptors.

Mosapride can promote the release of acetylcholine by stimulating the 5-HT receptors of the cholinergic intermediate nerves and myenteric plexus in the gastrointestinal tract, thereby enhancing gastrointestinal motility. Experimental results show that mosapride can enhance gastrointestinal motility, accelerate gastric emptying, and improve gastrointestinal function.

Dosage varies

Acofide hydrochloride is 100 mg three times a day. Mosapride can be taken orally before or after meals, 5 mg three times a day.

Adverse reactions

The most common side effects of Acofide hydrochloride are rash and vomiting, diarrhea, constipation, nausea, and urticaria. Common adverse reactions of Pili are diarrhea, loose stools, thirst, etc.

Summary

The above explains the differences between acotiamide hydrochloride (Acofide) and mosapride in terms of indications, drug properties, mechanisms of action, adverse reactions, etc. Patients should not blindly choose, and should follow the doctor's advice to choose the correct drug for treatment according to their own conditions.

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