那他珠单抗(Natalizumab)的副作用和不良反应

In addition to its desired efficacy, Natalizumab may cause some adverse effects. Although not all side effects will occur, if they do, medical intervention may be needed.

Side effects of Natalizumab (Natalizumab) Contact your doctor immediately

1. Common side effects

Bladder pain, blisters, scabs, irritation, itching or redness on the skin, bloody or turbid urine, substances produced by the body that can combine with the drug to reduce its efficacy or cause side effects, chest tightness, and cough , difficulty urinating, burning or pain, difficulty swallowing, dizziness, fast heartbeat, frequent urination, urgency, or increased need to urinate, hives, itching, rash, itching of the vagina or genital area, pain in the lower back or flanks, pain during intercourse, more frequent urination, swelling of the eyelids, around the eyes, face, lips, or tongue, thick white vaginal discharge that is colorless, odorless or with a slight odor, unusual tiredness, or weakness.

2. Rare side effects

Blurred vision, behavioral changes, chest pain, confusion, difficulty breathing or labored breathing, syncope or dizziness when suddenly standing up from lying or sitting position, fever, abnormal sensation Chills, fever, gas pain in the abdomen or stomach, nausea, redness of the face, neck, arms, and occasionally upper chest, chills, sneezing, sore throat, feeling of fullness in the stomach, sweating, suicidal thoughts, yellowing of the eyes or skin (jaundice).

3. Other side effects of unknown incidence

Some side effects usually do not require medical attention. These side effects may disappear during treatment as your body adjusts to the medication.

The pictures are from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

Side effects of Natalizumab (Natalizumab) seek medical attention immediately

1. Common side effects

Skin cracking, dryness, scaling, diarrhea, difficulty moving, discouragement, Feeling sad or empty, irregular periods, irritability, loss of interest or pleasure in things, muscle pain or stiffness, aches, cramps, or heavy bleeding (such as during menstruation), joint pain, stomach soreness or discomfort, swollen glands, trouble concentrating, trouble sleeping.

2. Rare side effects

No menstruation, missed or irregular menstruation, chest discomfort, local bleeding, trembling of legs, arms, hands or feet, amenorrhea, trembling of hands or feet.

Side Effect Management for Healthcare Professionals

1. Ocular Adverse Events

Incidence not reported: acute retinal necrosis, blindness, decreased visual acuity, redness, and eye pain.

2. Nervous system

(1), very common (10% or more): headache (38%).

(2) Common (1% to 10%): dizziness, drowsiness, tremor, and dizziness.

(3) Uncommon (0.1% to 1%): progressive multifocal leukoencephalopathy.

(4). Incidence not reported: Tremor.

3. Respiratory system

(1), very common (10% or more): upper respiratory tract infection (22%), lower respiratory tract infection (17%).

(2) Common (1% to 10%): sore throat, cough, sinusitis, nasopharyngitis.

4. Mental system

Very common (10% or more): depression (19%).

5. Gastrointestinal tract

(1), very common (10% or more): nausea (17%), gastroenteritis (11%), abdominal discomfort (11%), diarrhea (10%).

(2) Common (1% to 10%): indigestion, constipation, flatulence, aphthous stomatitis, tooth infection, tonsillitis.

(3). Incidence not reported: vomiting.

6. Immune system

(1). Very common (10% or more): influenza-like illness (12%).

(2). Common (1% to 10%): herpes, tonsillitis, viral infection, immunogenicity (production of anti-drug antibodies).

7. Hepatobiliary system

(1) Common (1% to 10%): Abnormal liver function tests.

(2). Post-marketing reports: severe liver damage, elevated liver enzymes, and hyperbilirubinemia.

8. Systemic reaction

(1), very common (10% or more): fatigue (27%).

(2) Common (1% to 10%): tooth infection, toothache, chills.

(3). Incidence not reported: flushing, chills, and fever.

9. Local reaction

Incidence not reported: local allergic reaction.

10. Genitourinary system

(1), very common (10% or more): urinary tract infection (21%), vaginitis (10%).

(2) Common (1% to 10%): irregular menstruation, dysmenorrhea, amenorrhea, ovarian cysts, urinary incontinence, urgency/frequency of urination.

11. Musculoskeletal system

(1), very common (10% or more): joint pain (19%), limb pain (16%), back pain (12%).

(2) Common (1% to 10%): chills, muscle spasms, and joint swelling.

12. Skin system

(1), very common (10% or more): rash (12%).

(2) Common (1% to 10%): dermatitis, itching, night sweats, dry skin, urticaria.

13. Anaphylaxis

(1) Common (1% to 10%): immediate or delayed allergic reaction, seasonal allergy.

(2). Incidence not reported: allergic reaction/anaphylactoid reaction.

14. Blood system

Rare (less than 0.1%): anemia, hemolytic anemia.

15. Metabolism/nutritional system

Common (1% to 10%): weight gain, weight loss, peripheral edema.

16. Cardiovascular system

Common (1% to 10%): chest discomfort.