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Merck can prevent acute and delayed nausea and vomiting caused by chemotherapy. Used in combination with steroids and 5-HT3 receptor antagonists to prevent and control nausea and vomiting caused by chemotherapy.

Merck is a company located in Kenilworth, New Jersey, USA, with approximately 70,000 employees worldwide (as of December 31, 2014). In 2014, Merck's global sales totaled US$42.2 billion, and its R&D investment reached US$6.5 billion.

Usage and dosage of MSD aprepitant:

In a combination regimen of aprepitant capsules with a corticosteroid and a 5-HT3 antagonist, aprepitant was administered for 3 days. Read the instructions for your 5-HT3 antagonist carefully before starting treatment. The recommended dose of aprepitant is 125 mg orally administered 1 hour before chemotherapy (Day 1) and 80 mg orally once daily in the morning on Days 2 and 3.

Precautions when using MSD aprepitant:

1. Aprepitant is a dose-dependent CYP3A4 inhibitor and must be used with caution in patients with drugs that are mainly metabolized by CYP3A4; some chemotherapy drugs are metabolized by CYP3A4. The moderate inhibition of CYP3A4 by aprepitant 125 mg/80 mg therapy may increase the plasma concentrations of these concomitantly administered drugs.

2. When used together with warfarin, the international normalized ratio (INR) of prothrombin time can be significantly reduced. Patients who require long-term treatment with warfarin should have their INR monitored closely for two weeks after starting the 3-day dosing regimen of aprepitant in each chemotherapy cycle, especially on days 7-10.

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Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.