昂丹司琼片的作用及用法

Ondansetron (trade name: Zofran) is a potent and highly selective 5-hydroxytryptamine (5-HT3) receptor antagonist and a powerful antiemetic. Ondansetron is a potent and highly selective 5-HT3 receptor antagonist first developed by GlaxoSmithKline (GSK) in 1990. It can inhibit nausea and vomiting caused by chemotherapy and radiotherapy in cancer patients. In 2014, Novartis acquired GSK’s oncology business, including ondansetron. Let’s learn about the function and usage of the following tablets.

Ondansetron can antagonize the 5-hydroxytryptamine receptors located in local nerves of the peripheral and central nervous system, and can effectively block the 5-hydroxytryptamine receptors in the vagal afferent terminals of the gastrointestinal mucosa to produce antiemetic effects. It has the effect of highly selectively inhibiting nausea and vomiting caused by radiotherapy and chemotherapy. Chemotherapy drugs and radiation therapy can cause the release of serotonin from the small intestine, which activates the afferent branch of the vagus nerve through serotonin receptors and triggers the gag reflex. The stimulation of the afferent branch of the vagus nerve can also cause the release of 5-hydroxytryptamine in the posterior area of ​​the bottom of the fourth ventricle, thus strengthening the vomiting reflex through the central mechanism. Ondansetron is mainly used for nausea and vomiting caused by radiotherapy and chemotherapy, and is also used to prevent and treat nausea and vomiting caused by surgery.

After receiving ondansetron tablets, patients must read the instructions carefully to understand the characteristics and contraindications of the drug. Then take the medicine in accordance with the doctor's instructions and do not take the medicine blindly. Pharmaceutical preparations of ondansetron include ondansetron hydrochloride tablets (capsules): (1) 4mg, (2) 8mg and ondansetron hydrochloride injection (1) 2ml: 4mg, (2) 4ml: 8mg. Oral administration: Take 8 mg 1 to 2 hours before radiotherapy. Injection medication: Administered through intravenous or intramuscular injection, and the dosage can be flexibly controlled.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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