意美止吐效果怎么样？

Yimei is a hard capsule containing off-white pellets. Aprepitant capsules, administered in combination with other antiemetic drugs, are indicated for the prevention of acute and delayed nausea and vomiting during initial and repeated treatment with highly emetogenic antineoplastic chemotherapy. It is a neurokinin-1 (NK-1) receptor blocker, which has been gradually promoted clinically in recent years. It can block NK-1 receptors with high selectivity and closely combine with it to inhibit vomiting caused by chemotherapy drugs. It is especially effective in preventing delayed vomiting.

Yimei is a selective high-affinity antagonist of the human substance P neurokinin 1 (NK1) receptor. Counter-screening analysis suggests that Yimei is at least 3,000 times more selective for the NK1 receptor than other enzymes, transporters, ion channels and receptor sites, including dopamine and serotonin receptors, compared to other drugs for the treatment of chemotherapy-induced vomiting (CINV). Preclinical studies have shown that NK1 receptor antagonists can centrally inhibit the vomiting induced by cytotoxic chemotherapy drugs, such as cisplatin.

Preclinical and human positron emission tomography (PET) studies on Yimei demonstrate that it can penetrate into the brain and occupy brain NK1 receptors. Preclinical studies have shown that Yimei has a longer duration of central activity, can inhibit cisplatin-induced acute and delayed phase vomiting, and enhances the antiemetic activity of the 5-HT3 receptor antagonist ondansetron and the glucocorticoid dexamethasone against cisplatin-induced vomiting.

It was officially approved for sale in China on August 22, 2014, and has also been included in the national medical insurance to provide everyone with government discounts to reduce the financial burden. The specifications of Yimei capsules after medical insurance are 3 capsules per box (0.125gx1 capsule + 80mgx2 capsules). The price of each box is about $600, which is still relatively high. According to Medical Companion Travel, we learned that the price of Yimei is about 60$, which is more suitable for patients to use for a long time. It is cheaper and more cost-effective. Since the exchange rate has been in a state of fluctuation for a long time, the price fluctuates with the exchange rate and is not static. For more information about Yimei, please contact Medical Companion Travel for details.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.