使用阿瑞匹坦需要注意什么？阿瑞匹坦怎么服用最好？

Aprepitant, administered in combination with other antiemetics, is indicated for the prevention of acute and delayed nausea and vomiting during initial and repeated treatment with highly emetogenic antineoplastic chemotherapy. By selectively antagonizing Aprepitant receptors, it blocks nausea and vomiting caused by cytotoxic substances. Currently, some clinical researchers say that (Aprepitant) receptor antagonists have a broader spectrum of activity against various emetics than 5-HT3 receptor antagonists, and have found that they have more prominent clinical effects on delayed vomiting. What should patients pay attention to when taking aprepitant? What is the best way to take aprepitant?

Generally, Aprepitant should be placed in a dry place at 15 to 25 degrees Celsius, and refrigerated medicines should be placed in a refrigerator at 2 to 8 degrees Celsius (do not freeze); if it deteriorates or expires, it should not be eaten.

The effectiveness of oral contraceptives may be reduced during long-term use of Aprepitant. Although the effects of a three-day regimen of aprepitant on oral contraceptives have not been studied, an additional alternative or complementary method of contraception should be used during use of aprepitant.

Aprepitant (Aprepitant) may induce adverse reactions in infants who drink breast milk, so the nature of this drug to the mother must be considered and a choice should be made between stopping breastfeeding or stopping the drug.

Corrections must be made when treating patients concomitantly with Aprepitant and drugs that are primarily metabolized by the CYP3A4 enzyme; some chemotherapy drugs are metabolized by the CYP3A4 enzyme. The inhibitory effect of Aprepitant on CYP3A4 will lead to increased blood concentrations of these concomitant drugs.

How to use aprepitant

Aprepitant is a three-day intervention and consists of a course of treatment with a corticosteroid and a 5-HT3 antagonist.

The recommended dose of Aprepitant is 125 mg taken orally one hour before chemotherapy on Day 1 and 80 mg once daily in the morning on Days 2 and 3.

The above is the introduction about Aprepitant, I hope it can help everyone.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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