昂丹司琼儿童可以用吗？昂丹司琼禁用人群有哪些？

Ondansetron is a potent, highly selective 5-HT3 receptor antagonist with strong antiemetic effects. Chemotherapy drugs and radiotherapy can cause the small intestine to release 5-HT, which activates the afferent branches of the vagus nerve through 5-HT3 receptors, triggering the vomiting reflex, and can prevent vomiting. It is an antiemetic drug. So, can ondansetron be used by children? Who is contraindicated on ondansetron?

Ondansetron is contraindicated in the following situations: Patients with a known hypersensitivity reaction (e.g., anaphylaxis) to ondansetron or any component of the formulation. The second scenario is the concurrent use of apomorphine. The third situation is that it should not be used in patients with gastrointestinal obstruction. The use of ondansetron is prohibited in the above three situations.

Patients should also pay attention to the following when using ondansetron:

Patients with kidney damage do not need to adjust the dosage, frequency and route of administration of ondansetron. For specific usage, you can consult your doctor or read the instructions.

Also, ondansetron hydrochloride tablets should not be used after abdominal surgery to avoid masking symptoms of ileal or gastric dilation.

In patients with liver function impairment, the ability to clear ondansetron from the body is significantly reduced in patients with moderate or severe liver function impairment, and the serum half-life is also prolonged. Therefore, the daily dose of ondansetron in such patients should not exceed 8 mg.

Ondansetron also has adverse reactions: patients who use Shudan (ondansetron hydrochloride) may experience headaches, abdominal discomfort, constipation, occasional bronchial asthma or allergic reactions, transient asymptomatic increases in transaminases, dry mouth, rash, etc. The above reactions are mild and do not require special treatment. There are rare reports of individual patients having epileptic seizures and chest pain, arrhythmia, hypotension, and bradycardia.

The mechanism of post-operative nausea and vomiting is unknown, but it may be induced by a common pathway similar to cytotoxic drugs that cause nausea and vomiting. Ondansetron exerts an antiemetic effect on nausea and vomiting caused by chemotherapy and radiotherapy by antagonizing the 5-HT receptors of neurons located in the peripheral and central nervous system.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

Recommended related articles: