阿瑞匹坦多少钱一盒?在哪里购买?

This article will discuss the price, purchase channels and pharmacokinetics of aprepitant in detail. This information is presented to provide a comprehensive reference guide for patients and healthcare professionals. The article covers the prices, purchase methods, and absorption, distribution, and metabolism processes of different versions of aprepitant in the body.

How much does a box of Aprepitant cost?

The price of Greenmark Pharmaceutical Factory in India

The specifications of Aprepitant capsules produced by Greenmark Pharmaceutical Factory in India are 125mg*1 capsule + 80mg*2 capsules, and the price per box is about US$9. The price is attractive for patients who need to take the drug long-term.

Domestic generic drug prices

In the domestic market, Qilu Pharmaceutical launched the first generic capsule "Oukeping", and Chia Tai Tianqing Pharmaceutical, Nanjing Entai Pharmaceutical and others have also launched generic products. Due to competition from domestic generic drugs, the price has dropped compared to the original drug, but the specific price will vary depending on the region and medical insurance policies.

Price of injection dosage forms

Although the aprepitant injection developed by Heron Therapeutics has been approved abroad, it has not been widely used in China. Injections are relatively expensive and are mainly used for patients who are not suitable for oral medications.

Where to buy aprepitant

Regular pharmacies and hospitals

In China, patients can obtain aprepitant through regular pharmacies or hospitals. These channels often provide quality-assured products and can provide specific advice on medication from a pharmacist or doctor.

Online platform

With the development of the Internet, online drug sales platforms have also become a convenient way to purchase. However, you need to be careful when choosing this method to ensure that the platform is legal and compliant to avoid purchasing fake medicines.

Overseas medical service institutions

For patients who cannot buy the drugs they need in China under certain circumstances, purchasing drugs through reliable overseas medical service institutions is also an option. However, this method may increase logistics time and costs.

Pharmacokinetics of aprepitant

Oral bioavailability

The oral bioavailability of aprepitant is 60%-65%, and the time to reach peak concentration is approximately 4 hours. Food has little effect on drug absorption and can be taken before or after meals.

Protein binding rate and volume of distribution

The protein binding rate of aprepitant exceeds 95%, and the apparent volume of distribution is approximately 70L, indicating that it can be widely distributed in body tissues and can penetrate the blood-brain barrier, which is particularly important for the treatment of nausea and vomiting caused by chemotherapy.

Metabolism and Excretion

Mainly metabolized through the CYP3A4 enzyme system, with a half-life of 9-13 hours. Approximately 57% of the drug is excreted in the urine and 45% in the feces. Renal insufficiency does not significantly affect the clearance of aprepitant, but patients with severe hepatic impairment need to be carefully monitored for adverse effects.