埃索美拉唑作用功效

It is used for the treatment of gastroesophageal reflux disease (GERD), including the treatment of erosive reflux esophagitis, long-term maintenance treatment to prevent recurrence of cured esophagitis patients, and symptom control of gastroesophageal reflux disease (GERD). Esomeprazole combined with appropriate antimicrobial therapy can eradicate Helicobacter pylori, heal duodenal ulcers associated with Helicobacter pylori infection, and prevent the recurrence of peptic ulcers associated with Helicobacter pylori infection.

Esomeprazole is the S-isomer of omeprazole. It reduces gastric acid secretion through a specific targeting mechanism and is a specific inhibitor of proton pumps in parietal cells. The R-isomer and S-isomer of omeprazole have similar pharmacodynamic properties. The site and mechanism of action. Esomeprazole is a weak base, which is concentrated in the high-acid environment of the acid secretion microtubules of parietal cells and converted into an active form, thereby inhibiting the H+/K+-ATPase (proton pump) at this site, inhibiting both basal gastric acid secretion and stimulated gastric acid secretion.

In a clinical comparative study of esomeprazole and omeprazole in the treatment of reflux esophagitis, the total effective rate of esomeprazole was 97.18%, which was significantly higher than 84.51% of omeprazole, and there was no significant difference in the incidence of adverse reactions. Chen Caiming conducted a cost-effectiveness analysis of omeprazole and esomeprazole in the treatment of duodenal ulcer. The recovery rate of the esomeprazole group was 92.6%, which was higher than that of omeprazole, 78.6%. The results proved that esomeprazole has cost and effectiveness advantages. 

Esomeprazole maintains gastric pH >4 for a longer period of time. A study on the duration of gastric pH > 4 and the healing rate of reflux esophagitis showed that the longer the duration of pH > 4 within 24 hours, the greater the number of patients who healed after 8 weeks. After taking different drugs orally for 5 days, the duration of pH>4 in the stomach within 24 hours from longest to shortest is: esomeprazole 40 mg, omeprazole 40 mg, lansoprazole 30 mg, pantoprazole 40 mg and rabeprazole 20 mg. This shows that esomeprazole 40mg has a stronger acid-suppressing effect than other proton pump inhibitors. Clinical trials have also fully confirmed the excellent pH control ability of esomeprazole 40mg. Generally speaking, it is very effective in treating early-stage gastric cancer.