埃索美拉唑效果怎么样

(Nexium) Effects on the Pharmacokinetics of Other Drugs For drugs whose absorption is affected by gastric acid, the absorption of these drugs may be increased or decreased during esomeprazole treatment due to a decrease in gastric acidity. As with other oxyntic inhibitors or antacids, the absorption of ketoconazole and itraconazole may be reduced during treatment with esomeprazole (Nexium). Esomeprazole inhibits CYP2C19, the main enzyme metabolizing esomeprazole. Today we will learn more about the effectiveness of the Indian version of esomeprazole?

In a clinical comparative study of esomeprazole (Nexium) and omeprazole in the treatment of reflux esophagitis, the total effective rate of esomeprazole was 97.18%, which was significantly higher than 84.51% of omeprazole, and there was no significant difference in the incidence of adverse reactions. Chen Caiming conducted a cost-effectiveness analysis of omeprazole and esomeprazole in the treatment of duodenal ulcer. The recovery rate of the esomeprazole group was 92.6%, which was higher than that of omeprazole, 78.6%. The results proved that esomeprazole has cost and effectiveness advantages.

80 patients with gastroesophageal reflux disease who were treated from January 2011 to December 2013 were randomly divided into two groups, 40 cases in each group. The observation group was treated with standard dose of esomeprazole (Nexium), and the control group was treated with high-dose omeprazole. All groups were treated for 8 weeks. The relief of symptoms such as heartburn, acid regurgitation, chest pain, and dysphagia were observed before and after treatment, and the changes in symptom scores were counted. The SF-36 health scale was used to evaluate the changes in the patients' quality of life before and after treatment. SPSS was used 19.0 statistical software was used for data processing, the counting data were expressed as percentages, the comparison between groups was expressed by χ2 test, the measurement data was expressed as (xˉ±s), the comparison between groups was using independent sample t test, and the comparison before and after treatment within the group was using paired t test. P0.05). The heartburn and chest pain relief rate of the observation group was higher than that of the control group (all P0.05).

After treatment, the physical pain, overall health, vitality, social function, emotional function and mental health of both groups were improved compared with before treatment (all P<0.05); the physical pain, vitality and social function scores of the observation group were significantly higher than those of the control group (all P<0.05). Conclusion Compared with high-dose omeprazole, conventional dose esomeprazole (Nexium) can more effectively relieve the clinical symptoms of patients with gastroesophageal reflux. In addition, it has obvious advantages in improving patients' quality of life and is worthy of application.

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