耐信作用与功效

In 2000, the oral formulation of (esomeprazole) was first launched in Sweden. In 2001, it was approved by the FDA to be launched in the United States under the trade name Nexium. On July 30, 2020, AstraZeneca announced that China’s National Medical Products Administration (NMPA) officially approved Nexium (esomeprazole sodium) injection for the prevention of stress ulcer bleeding in severe patients. Today we will learn more about the functions and effects of Nexium.

Nexium (esomeprazole) is the S-isomer of omeprazole. It reduces gastric acid secretion through a specific targeting mechanism and is a specific inhibitor of proton pumps in parietal cells. The R-isomer and S-isomer of omeprazole have similar pharmacodynamic properties. The site of action and mechanism of Nexium is a weak base, which is concentrated in the high-acid environment of the acid secretion microtubules of parietal cells and converted into an active form, thereby inhibiting the H+/K+-ATPase (proton pump) at this site and inhibiting both basal gastric acid secretion and stimulated gastric acid secretion.

Nexium (esomeprazole) indications:

1. Nexium is used for the treatment of gastroesophageal reflux disease (GERD), including the treatment of erosive reflux esophagitis, long-term maintenance treatment to prevent recurrence of cured esophagitis patients, and symptom control of gastroesophageal reflux disease (GERD).

2. Nexium combined with appropriate antibacterial therapy can eradicate Helicobacter pylori, heal duodenal ulcers related to Helicobacter pylori infection, and prevent the recurrence of peptic ulcers related to Helicobacter pylori infection.

In a clinical comparative study between Nexium and omeprazole in the treatment of reflux esophagitis, the total effective rate of Nexium (esomeprazole) was 97.18%, which was significantly higher than 84.51% of omeprazole, and there was no significant difference in the incidence of adverse reactions. Chen Caiming has done a cost-effectiveness analysis of omeprazole and Nexium in the treatment of duodenal ulcer. The recovery rate of the Nexium group was 92.6%, which was higher than omeprazole's 78.6%. The results proved that Nexium has cost and effect advantages.

When taking Nexium (esomeprazole), the tablets should be swallowed whole together with the liquid. They should not be chewed or crushed, otherwise the efficacy of the medicine will be affected. For patients who cannot swallow, Nexium can be dissolved in carbonate-free water and administered through a gastric tube.

The above is the function of (esomeprazole), I hope it can help you!

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