耐信是饭前服用还是饭后服用？

(Esomeprazole) has been approved for indications in Japan including reflux esophagitis and non-erosive reflux disease (NERD). On July 30, 2020, AstraZeneca announced that China’s National Medical Products Administration (NMPA) had officially approved Nexium injection for the prevention of stress ulcer bleeding in severe patients. Today we will learn more about whether Nexium should be taken before meals or after meals?

1. Treatment of erosive reflux esophagitis: Nexium (esomeprazole) 40 mg once a day for 4 weeks. For patients whose esophagitis is not cured or whose symptoms persist, a further 4 weeks of treatment is recommended.

2. Long-term maintenance treatment for cured esophagitis patients to prevent recurrence: 20 mg once a day.

3. Symptom control of GERD (gastroesophageal reflux disease): patients without esophagitis take 20 mg once a day. If symptoms are not controlled after 4 weeks of medication, the patient should undergo further examination. After the symptoms disappear, immediate therapy can be used (ie, 20 mg orally, once a day if necessary).

4. Combined antimicrobial therapy to eradicate Helicobacter pylori: Use a combined medication regimen, including Nexium (esomeprazole) 20 mg once, amoxicillin 1g once, and clarithromycin 500mg once, all twice a day for 7 days.

Tablets should be swallowed whole with liquid and should not be chewed or crushed.

For patients with difficulty swallowing, put it into boiled water until the tablet is completely disintegrated and take it within 30 minutes.

In the acute phase of peptic ulcer, patients should eat small and frequent meals while taking Nexium (esomeprazole), and they can eat every 2 hours during the day to reduce the change in gastric acidity. After the symptoms are under control, you should resume your usual three meals a day. At the same time, you should avoid eating snacks or late-night snacks, and do not lie down to rest after meals.

Nexium (esomeprazole) is the S-isomer of omeprazole. It reduces gastric acid secretion through a specific targeting mechanism and is a specific inhibitor of proton pumps in parietal cells. 

In a clinical comparative study of Nexium and omeprazole in the treatment of reflux esophagitis, the total effective rate of Nexium was 97.18%, which was significantly higher than 84.51% of omeprazole, and there was no significant difference in the incidence of adverse reactions. Chen Caiming has done a cost-effectiveness analysis of omeprazole and Nexium in the treatment of duodenal ulcer. The recovery rate of the Nexium group was 92.6%, which was higher than omeprazole's 78.6%. The results proved that Nexium has cost and effect advantages. 

The above is the content of how to take (esomeprazole), I hope it can help you!

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