耐信的作用和副作用

When esomeprazole is used for Helicobacter pylori eradication treatment, possible drug interactions with all components of the triple therapy should be considered. Clarithromycin is a potent inhibitor of CYP 3A4. Therefore, the contraindications and interactions of clarithromycin should be considered when patients on triple therapy are concurrently taking other drugs that are also metabolized by CYP 3A4, such as cisapride. Today we will learn more about the functions and side effects of Nexium.

Nexium (esomeprazole) is the S-isomer of omeprazole. It reduces gastric acid secretion through a specific targeting mechanism and is a specific inhibitor of proton pumps in parietal cells.

In a clinical comparative study of Nexium and omeprazole in the treatment of reflux esophagitis, the total effective rate of Nexium was 97.18%, which was significantly higher than 84.51% of omeprazole, and there was no significant difference in the incidence of adverse reactions. Chen Caiming has done a cost-effectiveness analysis of omeprazole and Nexium in the treatment of duodenal ulcer. The recovery rate of the Nexium group was 92.6%, which was higher than omeprazole's 78.6%. The results proved that Nexium has cost and effect advantages.

Nexium (esomeprazole) side effect incidence >10%: Central nervous system: headache (2%-11%). 

The incidence rate of Nexium side effects is 1%-10%: central nervous system: irritability (infants: ≥5%), dizziness (intravenous injection: ≤3%; oral administration: <1%), dizziness (intravenous injection: ≤3%), drowsiness (children: 2%;).

Nexium (esomeprazole) side effect incidence rate <1%) Dermatology: pruritus (intravenous injection: 1%; oral: <1%), endocrine and metabolism: changes in thyroid hormone levels (increased thyroxine: ≤1%), decreased serum potassium (≤1%), decreased serum sodium (≤1%), decreased thyroid hormone (decreased thyroxine: ≤1%), increased gastrin (≤1%), increased serum potassium (≤1%), increased serum sodium (≤1%), increased thyroid-stimulating hormone (≤1%), increased uric acid (≤1%).

When any alarm symptoms occur (such as significant involuntary weight loss, repeated vomiting, dysphagia, hematemesis or melena), gastric ulcer is suspected or gastric ulcer is already present, malignant tumors should be excluded, because treatment with Nexium can reduce symptoms and delay diagnosis.

The above is the content of the effects and side effects of (esomeprazole), I hope it can help you!

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