埃索美拉唑(耐信)好不好

For many patients with gastric problems, the drug name omeprazole may not be unfamiliar. It is the first proton pump inhibitor, but it is the S-isomer of omeprazole. There is a close relationship between the structures. It belongs to the second generation of proton pump inhibitors, also known as Nexium's current main indications include the treatment of gastroesophageal reflux disease (GERD) and erosive reflux esophagitis; long-term maintenance treatment to prevent recurrence of cured esophagitis patients; and symptom control of gastroesophageal reflux disease (GERD).

In addition, esomeprazole (Nexium) combined with appropriate antibacterial therapy eradicates Helicobacter pylori and heals duodenal ulcers associated with Helicobacter pylori infection and prevents the recurrence of peptic ulcers associated with Helicobacter pylori infection.

Esomeprazole (Nexium) has been on the market in my country for many years, but many patients are still unclear about its effect. So is esomeprazole good?

Esomeprazole mainly reduces gastric acid secretion through a specific targeting mechanism. Its mechanism of action is as follows: Esomeprazole is a weak base, which is concentrated in the high-acid environment of parietal cell acid secretion microtubules and converted into an active form, thereby inhibiting the H/K-ATPase (proton pump) at this site, inhibiting both basal gastric acid secretion and stimulated gastric acid secretion.

In clinical trials, by comparing the effects of esomeprazole (Nexium) and omeprazole, it was found that esomeprazole has a better effect on reflux esophagitis. The total effective rate of the two is 97.18% vs. 84.51%. Esomeprazole is significantly higher than omeprazole, and there is no big difference in adverse reactions, which means the safety is better. In the cost-effectiveness analysis of the two drugs for the treatment of duodenal ulcer, the results showed that the recovery rates of the esomeprazole group and the omeprazole group were 92.6% vs. 78.6%, proving that esomeprazole has cost and effectiveness advantages.

Due to its high bioavailability, strong and long-lasting effect in inhibiting gastric acid, and low side effects, it is popular in the market. It has now become a leader in the peptic ulcer drug market.

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