如何缓解氯法齐明带来的不良反应？

Clofazimine is the drug of choice for the treatment of neoplastic leprosy. It is also used clinically for patients who are intolerant to sulfone drugs. In addition, clofazimine also has certain effects on chronic discoid lupus erythematosus, skin ulcers, and pyoderma gangrenosum. Clofazimine has positive effects on leprosy. Clofazimine also has obvious effects on patients with tumors that are resistant to sulfone drugs. It is manifested in the reduction of skin lesions and the significant decrease in bacterial morphological index. The therapeutic effect is remarkable, but treatment with this drug will also produce certain side effects or adverse reactions. What are the side effects of clofazimine? How to alleviate it?

Common adverse reactions of clofazimine include: skin redness and pigmentation/dry skin and ichthyosis-like changes/nausea/vomiting/anorexia/abdominal pain/constipation/diarrhea, etc.

How to alleviate the adverse reactions caused by clofazimine?

Skin redness and pigmentation: the most common, usually appearing 2 to 4 weeks after taking the drug, and most obvious at 6 to 12 months. The skin will appear light red at first, and then turn from tan to purple-black, making the exposed parts more obvious. In addition, the conjunctiva, urine, sputum, and sweat all appear red. Clofazimine can pass through the placenta and enter breast milk, causing skin staining in newborns and infants. The degree of skin redness and pigmentation is directly proportional to the dose and course of treatment, and will gradually subside after stopping the drug.

Dry skin and ichthyosis-like changes: mostly appear 2 to 3 months after taking the drug, and are most obvious on the extended sides of the limbs (especially the lower limbs). They gradually subside about 3 months after stopping the drug. Topical emollients can alleviate the symptoms.

Gastrointestinal reactions: A few patients have adverse reactions such as nausea, vomiting, anorexia, abdominal pain, constipation and diarrhea, which are generally mild and do not affect treatment. Taking clofazimine with food can alleviate the symptoms. If the abdominal pain is severe, the medication should be discontinued.

Clofazimine Precautions

According to relevant research, it is not recommended to take clofazimine soft capsules regularly to treat leprosy. The combined use of other drugs for treating leprosy can slow down the drug resistance of clofazimine soft capsules. It is recommended to use the drug under the guidance of a doctor or pharmacist. Drug resistance refers to the tolerance of microorganisms, parasites and tumor cells to the effects of chemotherapy drugs. Once drug resistance occurs, the chemotherapy effect of the drugs will be significantly reduced.

Different patients, different ages, and different symptoms will affect the dosage of clofazimine. The use of this drug must be fully considered based on the advice of your doctor. Two weeks after treatment with clofazimine, patients will develop red staining of the skin and mucous membranes that appears pink and brown. After stopping the drug for 2 months, the patient's pigment gradually decreased and gradually disappeared within about 1-2 years.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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