山德士诺华公司的甲氨蝶呤片是什么药？

Methotrexate tablets (Methotrexate) from Sandoz Novartis is an anti-folate anti-tumor drug that entered the field of tumor treatment more than half a century ago due to its anti-cell proliferation effect. Sandoz is a business unit of Novartis and a global leader in generic medicines and biosimilars. It is the second largest generic drug company in the world, producing and providing branded generic drugs of international quality and affordable prices. Its products are sold in more than 130 countries, covering 90% of the world's population. The main treatment areas include tumors, digestion, central nervous system and cardiovascular. What kind of medicine is Sandoz Novartis?

The main ingredient of methotrexate tablets is methotrexate. Methotrexate is an antimetabolite drug that is a folate reductase inhibitor, and tetrahydrofolate is an important coenzyme for the synthesis of purine nucleotides and pyrimidine deoxynucleotides in the body. Methotrexate can inhibit the reduction of dihydrofolate into tetrahydrofolate, thereby blocking the biosynthesis of DNA. Methotrexate mainly acts on the S phase of the cell cycle and is a cell cycle-specific drug.

The indications of methotrexate tablets include: (1) Systemic medication to treat choriocarcinoma, malignant mole, various types of acute leukemia and breast cancer, lung cancer, head and neck cancer, digestive tract cancer, cervical cancer and malignant lymphoma, etc. (2) Arterial cannulation infusion has a good effect on head and neck cancer and liver cancer. (3) High-dose methotrexate supplemented with calcium leucovorin rescue (HDMTX-CFR therapy), as a treatment for osteosarcoma, soft tissue sarcoma, malignant lymphoma, acute lymphocytic leukemia, breast cancer, and ovarian cancer. Postoperative adjuvant chemotherapy or systemic therapy for advanced lesions such as small cell lung cancer has certain effects.

Low-dose methotrexate tablets rarely produce serious side effects. Common side effects include mild gastrointestinal reactions, bone marrow suppression, liver damage, etc. Judging from the current evaluation conclusions, the benefits of correct use of methotrexate tablets outweigh the risks. However, given that there are cases at home and abroad of poisoning caused by incorrect dosage or frequency of medication, medical staff and patients are reminded to pay attention to the risk of misuse of methotrexate tablets.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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