阿普斯特适应症

It is an oral small molecule phosphodiesterase (PDE4) inhibitor that regulates the network of pro-inflammatory and anti-inflammatory mediators in cells. PDE4 is a cyclic adenosine monophosphate (cAMP)-specific PDE and the major PDE in inflammatory cells. PDE4 inhibition can increase intracellular cAMP levels and accordingly downregulate the inflammatory response by regulating the expression of TNF-α, IL-23 and other inflammatory cytokines. Elevated cAMP also increases anti-inflammatory cytokines such as IL-10.

Indications of Apremilast:

1. Suitable for patients with moderate to severe plaque psoriasis who receive phototherapy or systemic treatment;

2. Adult patients with active psoriatic arthritis;

3. Adult patients with oral ulcers related to Behcet's disease.

Apremilast is the first oral drug approved for the treatment of psoriasis in the past 20 years and the first oral drug approved for psoriatic arthritis in the past 15 years.

Usage and dosage of Apremilast:

1. In order to reduce gastrointestinal symptoms, adjust the dose to the recommended dose of 30 mg twice a day according to the following dosing schedule.

(1) Day 1: 10 mg in the morning;

(2) Day 2: 10 mg in the morning and 10 mg in the evening;

(3) Day 3: 10 mg in the morning and 20 mg in the evening;

(4) Day 4: 20 mg in the morning and 20 mg in the evening;

(5) Day 5: 20 mg in the morning and 30 mg in the evening;

(6) Day 6 and later: 30 mg twice daily.

2. Dosage in severe renal impairment: The recommended dose is 30 mg once daily.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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