【托法替尼临床效果】托法替尼治疗银屑病效果怎么样？几天见效？

Tofacitinib (tofacitinib) is a new type of Janus kinase inhibitor developed by Pfizer of the United States. It can effectively selectively inhibit JAK3, and also inhibits JAK1 and JAK2. It can block a series of cytokine signaling pathways mediated by JAKs in a system with abnormal cytokine levels, inhibit the transmission of abnormal immune signals, effectively control the course of RA, and has a weak inhibitory effect on other tyrosine kinases, which can reduce the scope of adverse reactions.

The U.S. Food and Drug Administration (FDA) approved it in November 2012 for the treatment of moderately to severely active rheumatoid arthritis (RA) in adults. Studies of the efficacy of tofacitinib (tofacitinib) in the treatment of adults with severe chronic plaque psoriasis are also ongoing.

How effective is tofacitinib in treating psoriasis? How many days does it take to take effect?

A clinical study evaluated the efficacy of tofacitinib in the treatment of psoriasis. The study included 1196 patients with psoriasis. Patients in the trial were randomized in a 2:2:1 ratio to receive 5 mg or 10 mg of tofacitinib or placebo twice daily. The trial results showed that tofacitinib significantly improved the clinical effects of psoriasis patients compared with placebo, and the severity of the patient's Psoriasis Severity Index (NAPSI) was improved. Study data showed that during the discontinuation period, a greater proportion of patients in the group who continued to receive tofacitinib maintained their treatment response compared with the group of patients who switched to placebo.

The time it takes for tofacitinib to be effective in the treatment of psoriasis varies from person to person, and the effect and time it takes for different patients to take tofacitinib (tofacitinib) treatment will be different.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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