罗氟司特乳膏的副作用和处理方法？

The side effects mainly include diarrhea, headache, insomnia, etc., which need to be treated in a targeted manner according to the specific symptoms. If necessary, you can seek medical treatment in time and carry out targeted treatment under the guidance of a doctor.

Roflumilast cream side effects

The most common symptoms of roflumilast cream include diarrhea, headache, insomnia, nausea, pain at the topical application site, upper respiratory tract infection, urinary tract infection, etc.

Because clinical trials of adverse reactions are conducted under a variety of different conditions, the incidence of adverse reactions observed in the clinical trials of one drug cannot be directly compared with the incidence in the clinical trials of another drug, nor does it reflect the incidence observed in practice.

How to deal with side effects of roflumilast cream

1. Diarrhea: When experiencing diarrhea, pay attention to drink plenty of water to replenish moisture, such as boiled water, watermelon juice, freshly squeezed juice, etc., to prevent dehydration, and avoid eating raw, cold, and irritating foods, such as cold drinks, peppers, etc. If the diarrhea is severe and frequent, you can consider using antidiarrheal drugs. The more commonly used one is montmorillonite powder, which has a better antidiarrheal effect.

2. Headache: Patients need to ensure sufficient rest time during medication to avoid fatigue or staying up late. Headaches can be relieved by hot compresses on the forehead, massage and other methods. If the headache worsens, consider using non-steroidal anti-inflammatory drugs, such as ibuprofen.

3. Insomnia: Try not to take a long nap during the day, develop good work and rest habits, go to bed early and get up early, and try to go to bed at 10 o'clock every night. Do not engage in strenuous exercise before going to bed, and do not drink irritating drinks such as coffee and strong tea to avoid aggravating insomnia.

4. Nausea: Pay attention to adjusting your diet, avoid eating greasy food, drink warm water, avoid dehydration caused by nausea and vomiting, eat small meals frequently, eat in moderation, avoid overeating, avoid inhaling irritating gases, ensure the living environment is clean and hygienic, and open windows frequently for ventilation.

5. Pain at the site of external application: You can appropriately reduce the dosage of roflumilast cream or suspend its use to reduce irritation to the site of application and keep the site clean and hygienic.

6. Upper respiratory tract infection or urinary tract infection: antibiotics need to be used for anti-infective treatment under the guidance of a doctor.

Coadministration of roflumilast with systemic CYP3A4 inhibitors or dual inhibitors that inhibit both CYP3A4 and CYP1A2 may increase the systemic exposure of roflumilast and may lead to increased adverse reactions. The risks and benefits of concurrent use should be carefully weighed.

Coadministration of roflumilast with oral contraceptives containing gestodene and ethinyl estradiol may increase the systemic exposure of roflumilast and potentially result in increased adverse effects. The risks and benefits of concurrent use should be carefully weighed.

It is recommended that psoriasis patients use roflumilast cream under the guidance of a doctor, pay attention to adverse reactions, and adjust the treatment plan in a timely manner.

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