氘可来昔替尼治疗银屑病的副作用有哪些?

The side effects of deuterated coxitinib in the treatment of psoriasis include upper respiratory tract infections (including upper respiratory tract infections, nasopharyngitis, pharyngitis, sinusitis, rhinitis, rhinotracheitis, tracheitis, laryngitis and tonsillitis), increased blood creatine phosphokinase, herpes simplex, oral ulcers, folliculitis, acne, etc. The patient's physical constitution and condition are different, and the performance after taking the drug is also different.

Treatment of side effects of deuterated colexitinib

1. Upper respiratory tract infection: usually caused by viruses. Patients need to drink plenty of water, rest appropriately, keep indoor air fresh, gargle with salt water and throat, avoid contact with irritating substances and avoid infecting others. If symptoms are severe or persist, consult your doctor.

2. Elevated blood creatine phosphokinase: Elevated blood creatine phosphokinase (CPK) may be related to muscle damage. You can rest, avoid strenuous exercise, and appropriately apply hot and cold compresses to relieve symptoms. If CPK continues to be elevated or is accompanied by other symptoms, consult your doctor.

3. Herpes simplex: This is an infectious disease caused by the herpes virus. Antiviral drugs can be used to relieve symptoms and good personal hygiene should be maintained. If symptoms are severe or come back frequently, talk to your doctor.

4. Oral ulcers: Oral ulcers can be relieved with mouthwash, oral gargle, or topical ointment. Keep your mouth clean and avoid spicy and acidic foods. If the ulcer is severe or lasts for a long time, talk to your doctor.

5. Folliculitis and acne: Keep your skin clean and avoid rubbing or squeezing acne. Topical medications may be used, such as antibiotic/anti-inflammatory ointments or ointments containing ingredients such as phenol or salicylic acid. If the condition is severe or ineffective, consult a dermatologist.

It should be noted that the above suggestions are for reference only. If symptoms continue to worsen or affect daily life, please consult a professional doctor promptly for accurate diagnosis and treatment advice.

Precautions for deuterated colexitinib

1. Hypersensitivity reactions, such as angioedema, have been reported in subjects who received it. If a clinically significant hypersensitivity reaction occurs, initiate appropriate treatment and discontinue deuterated colexitinib.

2. Deuterated colexitinib may increase the risk of infection. Patients with active or severe infections should avoid using deuterated colexitinib. If the patient develops a serious infection, discontinue deuterated colexitinib treatment. Do not restart deuteroclaxitinib treatment until the infection has resolved or been adequately treated.

3. Evaluate patients for latent and active TB infection before initiating treatment with deuterated colexitinib.

4. Consider the benefits and risks of individual patients (such as cancer patients) before initiating or continuing treatment with deuterated colexitinib.

5. Discontinue deuterated colexitinib if a significant increase in CPK (asymptomatic creatine phosphokinase) levels occurs or myopathy is diagnosed or suspected. Instruct patients to promptly report any unexplained muscle pain, tenderness, or weakness, especially if accompanied by malaise or fever.

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