阿普斯特的不良反应怎么处理?

Common adverse reactions of Apremilast include diarrhea, nausea, headache, and upper respiratory tract infection. Patients' physical constitution and condition are different, and their symptoms after taking the drug are also different. Some patients may experience hypersensitivity reactions.

Adverse reaction treatment of Apremilast

1. Diarrhea: Avoid overeating and consuming irritating foods, such as spicy, greasy or high-fiber foods. Maintain adequate fluid intake to avoid dehydration. Consider using an antidiarrheal medication such as loperamide, but only with your doctor's advice. If symptoms persist or worsen, seek medical advice as soon as possible and receive professional treatment.

2. Nausea: Avoid overeating and reduce the burden on the stomach. Avoid greasy, spicy or spicy foods. Consider taking antiemetic drugs such as metoclopramide, but only with your doctor's advice. If symptoms persist or worsen, seek medical attention as soon as possible.

3. Headache: Get enough rest and sleep. Avoid excessive use of electronic products such as cell phones and computers. Consider using over-the-counter pain relievers, such as ibuprofen, to relieve pain, but only under the guidance of a doctor. If symptoms persist or worsen, it is recommended to seek medical treatment.

4. Upper respiratory tract infection: Ensure adequate fluid intake to help expel phlegm and keep mucous membranes moist. Depending on the severity of symptoms, consider using antipyretic analgesics, cough suppressants, etc. If symptoms persist or worsen, it is recommended to seek medical advice and receive professional treatment.

5. Hypersensitivity reaction: Inform patients that hypersensitivity reactions may occur after taking tablets. If the patient has symptoms of allergic reaction, please contact the doctor in time and adjust the medication under the guidance of the doctor.

Precautions for Apremilast

1. Monitor patients who are more likely to develop diarrhea or vomiting complications. Patients who reduce their dose or discontinue Apremilast tablets generally improve more quickly. If a patient develops severe diarrhea, nausea, or vomiting, consider reducing or discontinuing Apremilast tablets.

2. Treatment with Apremilast is associated with an increased incidence of depression. Prescribers should carefully weigh the risks and benefits of Apremilast tablets before using them in patients with a history of depression and/or suicidal thoughts or behaviors. Patients, their caregivers, and families should be informed to be alert for the emergence or worsening of depression, suicidal thoughts, or other mood changes and to contact their physician promptly if such changes occur.

3. Patients receiving Apremilast tablets should monitor their weight regularly. If unexplained or clinically significant weight loss occurs, the weight loss should be evaluated and discontinuation of Apremilast tablets considered.

4. It is not recommended to use cytochrome P450 enzyme inducers (such as rifampin, phenobarbital, carbamazepine, phenytoin) together with Apremilast tablets. Co-administration of rifampicin, a strong cytochrome P450 enzyme inducer, results in reduced systemic exposure of Apremilast, which may result in the loss of the efficacy of Apremilast tablets.

The above are some of the measures and content of the side effects of Apremilast. For more details, you can read the drug instructions. It is recommended that patients take the medication under the guidance of a doctor and treat the symptoms accordingly.

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