罗氟司特乳膏的使用剂量和方法说明

导读：罗氟司特乳膏（Roflumilast Cream）是一种局部应用的磷酸二酯酶4（PDE4）抑制剂，用于治疗斑块型银屑病和特应性皮炎，临床试验结果表明，罗氟司特乳膏能够有效改善疾病症状，提高患者的生活质量，并且具有良好的安全性和耐受性。 This article details dosage, precautions, and drug interactions.

罗氟司特乳膏的使用剂量和方法

罗氟司特乳膏的推荐剂量是每日一次，开始治疗时，每日一次的剂量为250微克，持续4周。 Thereafter, the dose should be increased to 500 mcg once daily. Please note that the daily dose of 250 mcg is not an effective therapeutic dose. Apply roflumilast cream to the affected area and ensure complete absorption. If applied to hands, wash hands after use. If someone else helps apply, wash hands after application. Roflumilast cream is for topical use only and should not be used ocularly, orally, or vaginally.

Precautions for the use of roflumilast cream

After using roflumilast cream, avoid applying the drug to damaged skin to reduce the risk of systemic absorption. Roflumilast cream can be used in children 12 years and older, but its safety and effectiveness in children younger than 12 years have not been established. Roflumilast cream is contraindicated in patients with moderate to severe hepatic impairment (Child-Pugh class B or C). In clinical trials, no overall differences in safety or effectiveness were observed between older patients and younger patients, but caution is recommended. This drug should be used with caution in people who are pregnant or planning to become pregnant, and in patients who are breastfeeding or planning to breastfeed. While using the treatment, it may take several weeks for the patient to feel the effects of its treatment.

Drug interactions of roflumilast cream

The metabolism of roflumilast in the body involves the CYP3A4 enzyme system. Therefore, coadministration with known strong CYP3A4 inhibitors (such as ketoconazole, itraconazole, clarithromycin, etc.) or inducers (such as rifampicin, phenytoin, etc.) may affect the plasma concentration of roflumilast, thereby changing its efficacy or increasing the risk of adverse reactions. Concomitant use of other topical skin medications (such as corticosteroids, vitamin D analogs, etc.) with roflumilast cream may increase the risk of skin irritation or other local side effects. While using roflumilast cream, your doctor should be informed of all medications you are taking, including prescription drugs, over-the-counter drugs, vitamins, and herbal supplements, so your doctor can evaluate possible drug interactions.

Patients should follow their physician's instructions while using roflumilast cream and consult their physician before using any new medications or discontinuing existing medications. Physicians will evaluate potential drug interactions based on a patient's specific situation and provide appropriate recommendations. If you experience any unusual reactions or symptoms while using roflumilast cream, discontinue use immediately and seek medical help.