阿普斯特(MPRILA)导致的不良反应怎么治疗？

Introduction: Apremilast (MPRILA) is a drug for the treatment of certain types of psoriasis and psoriatic arthritis. Its trade name is Otezla. It is a selective phosphodiesterase 4 (PDE4) inhibitor. A series of adverse reactions may also occur during the medication process, which require corresponding treatment.

Adverse reactions caused by Apremilast (MPRILA)

Gastrointestinal reactions

Such as diarrhea, nausea, vomiting, abdominal pain, etc. These symptoms mostly occur in the early stages of treatment and usually gradually reduce or disappear within 1 month of medication.

Nervous system reactions

Nervous system reactions are also common side effects. Patients may experience symptoms such as headache, dizziness, drowsiness, and insomnia. In order to alleviate these symptoms, patients can try to maintain a good sleep state, avoid strenuous exercise, and take appropriate rest to reduce nervous system discomfort.

It also includes fatigue or burnout, loss of appetite, etc. During the period of using Apremilast, patients should communicate with their doctor regularly and closely monitor their body's response to ensure safety and efficacy.

How to treat adverse reactions caused by Apremilast (MPRILA)

Adjust the dosage or method of medication

For mild gastrointestinal reactions and nervous system reactions, patients can try to adjust the dosage or method of medication. For example, changing the once daily dose to twice daily or reducing the dose to a level that is tolerated by the patient. In addition, patients can also try different medication times under the doctor's advice, such as taking it after meals, to reduce irritation to the gastrointestinal tract.

Symptomatic treatment

For more serious adverse reactions, such as severe allergic reactions, cardiovascular system reactions, etc., patients should seek medical treatment immediately and follow the doctor's recommendations for symptomatic treatment. For example, for an allergic reaction, the patient may need to be treated with anti-allergy medications.

For cardiovascular system reactions, patients may need to adjust their cardiovascular medications. During the treatment process, patients should pay close attention to changes in physical condition and communicate with the doctor in a timely manner so that the doctor can adjust the treatment plan.

Lifestyle adjustment

Maintain good eating habits during medication, avoid eating greasy and irritating foods, and increase the amount of water you drink to replenish body fluids and salt to relieve gastrointestinal discomfort. Maintain a good sleep state and avoid strenuous exercise to reduce nervous system discomfort. Conduct regular physical examinations and monitor changes in key indicators such as liver function to detect and deal with possible problems in a timely manner.

Pharmacokinetics of Apremilast (MPRILA)

Apremilast is well absorbed in the intestine and has nothing to do with food intake. The plasma concentration reaches the peak after 2.5 hours, and the plasma protein binding rate is 68%. Apremilast is metabolized in the liver primarily by the enzyme CYP3A4 but to a lesser extent by CYP1A2 and CYP2A6.

The half-life of Apremilast is 6-9 hours. The substance is excreted through the kidneys and feces, mainly in the form of metabolites. Only 3% of the original substance is found in urine and 7% in feces.