阿普斯特(Apremilast)全网公布的2025年的最新价格

Introduction: Apremilast has been approved by the FDA for the treatment of adults with psoriatic arthritis with moderately to severely active disease, adults with plaque psoriasis who are candidates for phototherapy or systemic therapy, and adults with Behcet's disease associated with oral ulcers.

In 2025, the price of Apremilast across the entire network will show certain differences and volatility, but the overall trend will tend to be stable. This article will detail the latest price of Apremilast in 2025 and how to store it.

The latest price for 2025 announced by Apremilast across the entire network

The price varies depending on various factors such as version, region, sales channel, etc.

There are multiple versions of Apremilast on the market, such as the version produced by Glenmark in India and the version produced by Celgene in the United States. The Indian version is relatively low-priced and suitable for patients with limited financial conditions. For example, the price of the Indian Glenmark version of Apremilast in 30mg*30 capsules is about US$23 per box, and the price in 30mg*60 capsules is about US$33 per box. The American Celgene version is usually more expensive due to its higher branding and production costs, with a course of treatment costing about US$1,400.

The mechanism of action of Apremilast

Apremilast is a selective inhibitor of phosphodiesterase 4 (PDE4), which can prevent the conversion of cyclic adenosine monophosphate (cAMP) into AMP, further leading to the accumulation of cyclic adenosine monophosphate (cAMP) in cells. Inhibition of PDE4 is selective for the innate immune response and can reduce the production of inflammatory mediators such as CX-CL9, CX-CL10, IFN-γ, TNF-α, IL-2, IL-8, IL-12 and IL-23, further reducing the inflammatory response.

PDE4 inhibition has been reported to reduce inflammatory responses and bring therapeutic benefit and clinical improvement in psoriatic arthritis, plaque psoriasis, and Behcet's disease, although the specific mechanism of Apremilast is unclear and Apremilast has negligible inhibitory effects on other phosphodiesterases, receptors, or enzymes.

How to store Apremilast

The daily storage conditions of Apremilast are relatively loose. It can be sealed and stored at no more than 30℃. There is no need for refrigerated storage of biological agents. When storing Apremilast at home, patients should pay attention to avoid high temperature and humid environments and ensure that the drug packaging is intact. Check the expiry date of medicines regularly and avoid using expired medicines.

The treatment of psoriasis is a protracted battle. Only by improving medication compliance can symptoms be stably controlled and recurrence reduced. If the appearance of the medicine changes or there is a peculiar smell, consult a doctor or pharmacist in time and do not continue to use it.