贝罗司他胶囊是什么药?治疗效果好吗?

Berostat capsule Orladeyo is a plasma kallikrein inhibitor that binds to plasma kallikrein and inhibits its proteolytic activity. Currently, the capsule has been approved by the U.S. Food and Drug Administration (FDA) for the prevention of hereditary angioedema (HAE) attacks in children and adult patients aged ≥12 years. Today let’s learn about what kind of medicine is Berosstat Capsule? Is it effective in treating it?

Berosostat capsule Orladeyo is the first targeted oral therapy approved to prevent HAE attacks. The approval of berosostat capsules will bring significant progress in the treatment of HAE patients with hereditary angioedema and will help reduce the treatment burden on patients.

Berostat Oladejo is a novel, oral, once-daily, potent, selective human plasma kallikrein inhibitor that prevents edema attacks by inhibiting kallikrein to prevent the production of bradykinin. The most common adverse reactions (≥10%) with beroxostat are abdominal pain, vomiting, diarrhea, back pain, and gastroesophageal reflux disease.

In the pivotal Phase 3 APeX-2 trial, BioCryst significantly reduced the number of hereditary angioedema HAE attacks over 24 weeks and continued through week 48.

Patients who completed the 48-week trial experienced a significant reduction in the frequency of hereditary angioedema HAE attacks, from an average of 2.9 attacks/month at baseline to an average of 1 attack/month.

Completion of another long-term open-label APeX-S study reduced the frequency of HAE attacks in patients with hereditary angioedema to an average of 0.8 episodes per month.

It can be seen that the therapeutic effect of Orladeyo capsules is very significant, and the successful development of this drug is good news for many patients.

Recommended dose of Berostat: Take one capsule (150 mg) once daily with food. Patients should not increase or decrease the dosage of the drug without authorization during treatment with Orladeyo. Increasing the dosage of the drug will not make the condition improve quickly, but will lead to adverse reactions. Therefore, patients should strictly follow the doctor's diagnosis and treatment recommendations and should not use medication without authorization.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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