巴瑞替尼(艾乐明)治疗斑秃有副作用吗?

Baricitinib (Alemin) Side Effects in Alopecia Areata

The safety of Baricitinib (Alemin) was evaluated in two placebo-controlled trials in patients with severe alopecia areata.

The side effects of baricitinib (Ailemin) in the treatment of alopecia areata include upper respiratory tract infection, headache, acne, hyperlipidemia, elevated blood creatine phosphokinase, urinary tract infection, elevated liver enzymes, folliculitis, fatigue, lower respiratory tract infection, nausea, genital candida infection, anemia, neutropenia, abdominal pain, herpes zoster, and weight gain. The patient's physique and condition are different, and the adverse reactions after taking the drug will also be different.

Adverse reactions, including arterial thrombosis, B-cell lymphoma, lymphopenia, and dermatophytes, occurred in less than 1% of patients treated with baricitinib (Alemin) at any dose.

Other adverse reactions observed after 52 weeks: Venous thromboembolic events (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), and malignancies, including non-melanoma skin cancer.

Overall, the adverse effects observed in treated patients with alopecia areata were consistent with those seen in patients with rheumatoid arthritis. For more information about adverse reactions, click What are there?

Management of side effects of Baricitinib (Ailemin)

1. Headache: Mild headaches generally do not require special treatment. If the headache is severe and cannot be relieved, analgesic drugs may be considered.

2. Acne: Acne may occur during treatment. Acne can be treated, depending on the severity, with topical and oral medications.

3. Hyperlipidemia and elevated blood creatine phosphokinase: Blood lipids should be monitored regularly. If excessive blood lipids are found, diet control and drug treatment should be taken. An increase in blood creatine phosphokinase may occur during treatment with baricitinib. This increase may be due to muscle damage and this indicator should be monitored regularly.

4. Urinary tract infection: Drinking more water and urinating frequently can help prevent urinary tract infection. If symptoms of a urinary tract infection occur, they should be treated with appropriate antibiotics.

5. Elevated liver enzymes: Liver enzymes should be monitored regularly. If elevated liver enzymes are found, corresponding treatment measures should be taken.

6. Folliculitis: Mild folliculitis generally does not require special treatment. If the folliculitis is severe or persistent, topical drugs can be considered for treatment.

7. Nausea: If you feel nauseous, try eating small amounts and avoid greasy foods. If nausea is severe or persistent, talk to your doctor and adjust your treatment plan.

8. Anemia: If anemia occurs, you should pay attention to rest and supplement nutrition. If the anemia is severe or persistent, you should talk to your doctor and adjust your treatment plan.

9. Neutropenia: If neutropenia occurs, attention should be paid to preventing infection. If the white blood cell count continues to drop, talk to your doctor and adjust your treatment plan.

10. Abdominal pain: If you feel abdominal pain, try to stay warm and avoid irritating foods. If abdominal pain is severe or persistent, you should talk to your doctor and adjust your treatment plan.

11. Herpes zoster: If shingles occurs, you should seek medical treatment promptly and receive treatment according to the doctor's recommendations.

12. Weight gain: Patients receiving baricitinib should pay attention to controlling their diet and maintaining an appropriate amount of exercise to control their weight. If you continue to gain weight or are seriously overweight, talk to your doctor and take appropriate measures.

13. Fatigue, upper respiratory tract infection, lower respiratory tract infection: Pay attention to rest, maintain adequate sleep, and drink more water. If symptoms are severe or persistent, consider using antiviral drugs or antibiotics. If you feel severe or persistent fatigue, you should communicate with your doctor and adjust your treatment plan.

In summary, when using baricitinib to treat alopecia areata, you should pay close attention to your body’s reactions and symptoms and monitor them regularly. If any discomfort or suspected adverse reactions occur, you should communicate with your doctor promptly and take appropriate measures.

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