利特昔替尼导致的不良反应怎么治疗？

Introduction: Ritexitinib is an oral, specific Janus-related kinase inhibitor (mainly irreversible inhibition of JAK3), used to treat moderate to severe alopecia areata. Alopecia areata is an autoimmune disease characterized by hair loss leading to patches of scalp or even complete baldness, along with thinning or loss of eyebrows and eyelashes.

Adverse reactions caused by ritexitinib

As a Janus kinase (JAK) inhibitor, although it has shown certain efficacy in the treatment of alopecia areata, it is also associated with some side effects.

1. Adverse skin reactions: such as acne, rash, urticaria, folliculitis, atopic dermatitis, herpes zoster, etc.

2. Digestive system reactions: may include abdominal pain, nausea, diarrhea, etc.

3. Nervous system reaction: headache and dizziness.

4. Serious side effects: including serious infections, malignant tumors and lymphoproliferative diseases, thromboembolic events, hypersensitivity reactions, etc.

It should be noted that the incidence and severity may vary among individuals. Patients should strictly follow the doctor's instructions when using ritexitinib and communicate with the doctor in a timely manner if any adverse reactions occur.

How to treat the adverse reactions of ritexitinib

Ritexitinib may cause some side effects in the treatment of alopecia areata. The following are the measures to deal with these side effects.

1. Adverse skin reactions: Patients can try to use mild skin care products to avoid exposure to irritating environments. If discomfort persists or worsens, you should report it to your doctor promptly.

2. Digestive system reaction: During the medication period, patients can choose to take the medication with meals to relieve gastrointestinal discomfort. They should choose light, easy-to-digest foods and avoid spicy and greasy foods.

3. Nervous system reaction: Patients should maintain adequate rest during medication to avoid excessive fatigue. If symptoms of headache and dizziness persist or worsen, seek medical attention promptly. Medication dosage may need to be adjusted or other treatment options may need to be considered.

4. Hypersensitivity reaction: If a clinically significant hypersensitivity reaction occurs, ritexitinib should be discontinued and appropriate treatment should be carried out.

During the use of ritexitinib, patients should maintain close communication with their doctors, who will adjust the treatment plan according to the patient's specific conditions to ensure better results in the treatment of alopecia areata.

How to take ritixitinib

Ritexitinib is only available by prescription, and treatment must be initiated and supervised by a physician experienced in diagnosing and treating alopecia areata. Ritexitinib is an oral capsule that is taken once daily. If a patient develops a severe infection or low blood cell levels, treatment should be interrupted or stopped. If no improvement is seen after 36 weeks, treatment should be discontinued.

Ritexitinib is available by prescription only, and treatment must be initiated and supervised by a physician experienced in diagnosing and treating alopecia areata.