双氢睾酮外用凝胶:安全性、有效性与患者依从性分析

Introduction: Dihydrotestosterone topical gel is a kind of external male hormone gel that is applied externally through the skin to absorb the drug into the body. This drug is mainly used to replace testosterone in adult men to treat various health problems caused by testosterone deficiency, especially male hypogonadism. It is mainly used to treat low male testosterone levels, male sexual dysfunction, and is also used to treat male breast development and small penis. It has good efficacy and high safety.

Safety

It may cause some adverse reactions, such as skin irritation, extra hair growth, hoarseness, oily skin, etc. These are generally not serious and can be tolerated by patients. The safety profile of dihydrotestosterone topical gel varies among patients of different ages. Its safety and effectiveness have not been proven for men under 18 years of age, and inappropriate use may lead to problems such as accelerated bone age and excessive growth. Athletes should use dihydrotestosterone topical gel with caution as it contains active ingredients that may test positive in anti-doping tests. In patients with severe heart, liver, or kidney dysfunction, use of dihydrotestosterone may cause serious complications, such as edema and congestive heart failure.

Effectiveness

Dihydrotestosterone topical gel helps treat conditions related to imbalanced testosterone levels by regulating testosterone levels. Dihydrotestosterone (DHT) is a potent androgen that is essential for male genital development and, when used topically, has been shown to increase penile length and cause micropenis of various etiologies. Three 46,XY men with a confirmed p.L712F androgen receptor mutation who were of pre-pubertal, peri-pubertal, and adult age demonstrated varying degrees of micropenis correction after surgery, all of whom completed a 4-month course of daily dihydrotestosterone topical gel applied topically to the penis.

In prepubertal and peripubertal patients, stretched penile length changed from 2.5cm to 3.5cm (+40%) and from 3.5cm to 5.7cm (+63%), respectively. No additional changes in SPL were observed in adult patients treated with high-dose weekly testosterone for 1 year. Dihydrotestosterone topical gel is a safe and well-tolerated method of virilizing the micropenis in prepubertal and adolescent children with PAIS.

Patient Compliance

Dihydrotestosterone topical gel is for external use only. After cleaning, it should be evenly applied to the required skin area. The medication is more convenient and the patient's compliance is relatively high. Patients should follow their doctor's instructions when using dihydrotestosterone topical gel and strictly control the dosage and frequency of use. After taking the medicine, you should let the dihydrotestosterone topical gel dry for about 5 minutes before putting on clothes. It should be noted that the medicine should not be applied to damaged parts of the skin to avoid adverse irritation.