双氢睾酮外用凝胶的注意事项及作用功效概览

Introduction: Dihydrotestosterone topical gel is a prescription drug whose main ingredient is dihydrotestosterone and is produced by Besins International in France. This gel is mainly used to treat specific hormone deficiency symptoms. This article mainly talks about the precautions, drug interactions, use of specific groups of people, drug contraindications and efficacy of dihydrotestosterone topical gel.

Notes

Dihydrotestosterone gel is a prescription drug and must be used under the guidance of a doctor. Contraindicated in patients with male breast cancer or known or suspected prostate cancer. Not suitable for pregnant women, lactating women and women who may become pregnant. The gel is for external use only and should be applied to clean, dry skin. Leave it dry for about five minutes after application and avoid getting dressed immediately. Special caution is required when using it in elderly patients, especially due to the risk of worsening symptoms and signs of prostatic hypertrophy. There have been no formal studies in patients with renal or hepatic impairment and use should be done with caution.

Drug Interactions

Androgen therapy may affect insulin sensitivity or glycemic control, so patients with diabetes may need to adjust their insulin dose while using dihydrotestosterone gel. Patients taking anticoagulants may require more frequent monitoring of the international normalized ratio (INR) and prothrombin time, particularly during the initiation and discontinuation of androgen therapy. Increased fluid retention may occur when used concomitantly with corticosteroids, and caution should be monitored particularly in patients with cardiac, renal, or hepatic disease. Athletes should be aware when using it that dihydrotestosterone may cause positive anti-doping test reactions.

Use by specific groups

Pregnancy and breastfeeding: Disabled, may cause harm to fetus or nursing infant.

Children: Safety and effectiveness in males under 18 years of age have not been established.

Geriatric: Insufficient data are available to evaluate long-term safety data.

Contraindications

Dihydrotestosterone topical gel should not be applied to any damaged areas of skin. Avoid contact with eyes and mucous membranes. Pregnant women and women who may become pregnant should not handle dihydrotestosterone topical gel. Contraindicated in patients with male breast cancer or known or suspected prostate cancer.

Efficacy

Dihydrotestosterone is a metabolite of testosterone and has stronger biological activity. It mainly promotes sperm production by binding to the androgen receptor of spermatogenic cells. It also helps maintain the production of sperm, stimulates the development of reproductive organs, promotes the appearance and maintenance of normal male secondary sexual characteristics, maintains normal sexual desire, and promotes protein synthesis, especially in muscles and reproductive organs. It can also promote bone growth, calcium and phosphorus deposition, and red blood cell production.

It has many functions and potential therapeutic effects, but as a prescription drug, its use should follow the guidance of a doctor and pay attention to possible contraindications and drug interactions.