度他雄胺要吃多久？

Dutasteride is mainly used for the treatment of patients with prostatic hyperplasia. It can improve the symptoms of BPH for a long time. Dutasteride can also reduce the incidence of prostate cancer. Dutasteride is a new dual inhibitor of 5α-reductase, which inhibits both 5α-reductase-1 and 5α-reductase-2. It reduces DHT concentrations more than finasteride (94.7% vs. 70.8%). The inhibitory effect on 5α reductase-1 is 60 times that of finasteride. Twenty-seven months after taking dutasteride, the incidence of prostate cancer was 50% lower than in the placebo group.

Dutasteride is rapidly absorbed after oral administration, with a bioavailability of approximately 60%. When taking 0.5 mg orally, the plasma concentration reaches its peak in 2 to 3 hours. If taken with food, the peak concentration (Cmax) will be reduced by 10% to 15%. Dutasteride has a volume of distribution of 300 to 500L, a plasma protein binding rate of up to 99%, and an α1-acid glycoprotein binding rate of 96.6%. The drug concentration in the semen of healthy volunteers is 3.4ng/ml, which is similar to plasma. After 6 months of continuous use, the plasma drug concentration of dutasteride reaches a steady state. Dutasteride is extensively metabolized by hepatic cytochrome CYP3A4 and is mainly excreted in feces. Unmetabolized drugs account for 5%, metabolites account for 40%, and unmetabolized drugs account for less than 1% in urine. The elimination half-life of dutasteride is approximately 5 weeks.

How long should I take Dutasteride?

The duration of use of dutasteride by the patient needs to be determined according to the patient's own disease condition. Due to individual differences, the duration of use of dutasteride varies from person to person!

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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