度他雄胺和非那雄胺区别

Prostatic hyperplasia (BPH) is one of the common diseases in middle-aged and elderly men. The incidence of prostatic hyperplasia increases with age, but there may not be clinical symptoms when there are hyperplasia lesions. The incidence rate in urban areas is higher than that in rural areas, and racial differences also affect the degree of proliferation. Dutasteride (Avodart) and finasteride are both effective drugs for the treatment of prostatic hyperplasia. So what is the difference between them and finasteride?

The difference between dutasteride and finasteride

Dutasteride (Avodart) is a DHT inhibitor similar to finasteride. DHT is converted from testosterone under the action of 5-alpha-reductase. There are currently three types of 5α reductase, namely type I, type II and type III. Dutasteride (Avodart) is the first and currently the only drug that can inhibit both type I and type II 5α-reductase, while finasteride can only inhibit type II 5α-reductase.

Dutasteride (Avodart) is 3 times more effective than finasteride in inhibiting type I and 100 times more effective than finasteride in inhibiting type II. Dutasteride (Avodart) can reduce DHT in the serum by 90%, while finasteride can only reduce it by 70%; Dutasteride (Avodart) can reduce DHT in the scalp by 51%-79%, while finasteride can only reduce it by 34%-41%. Simply put, Dutasteride (Avodart) is a powerful all-around DHT inhibitor.

Dutasteride dosage and dosage

Adults, including the elderly: The recommended dose of Dutasteride (Avodart) is one 0.5 mg tablet, taken orally once daily. Dutasteride (Avodart) tablets should be swallowed whole and not chewed or opened. Dutasteride (Avodart) can be taken with or without food. Although symptomatic improvement is observed early in dutasteride treatment, it takes 6 months to achieve therapeutic effect. Patients should strictly follow the doctor's instructions during treatment with Dutasteride (Avodart), and should not increase or decrease the dosage of Dutasteride (Avodart) without authorization to avoid adverse reactions caused by increasing or decreasing the dosage.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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