5分钟带你走进传奇药物非那雄胺

After Finasteride received FDA certification in 1992, it was named Proscar and was officially put into use in the treatment of prostate. Clinical trials have proven that the effect of Proscar is indeed good. Except for some side effects with a very low incidence, most prostate problems in middle-aged and elderly people have been solved. But something even stranger happened. This drug for treating prostate can actually make people grow hair. After seeing the unexpected effect, Merck quickly developed a 1 mg version of finasteride and passed FDA certification.

Finasteride is a tetraazasteroid compound that inhibits the conversion of testosterone into dihydrotestosterone and has no affinity for the androgen receptor. More importantly, it does not affect the levels of other hormones, such as follicle-stimulating hormone, luteinizing hormone, corticosteroids, estradiol, prolactin and thyroxine, etc., and can better simulate the occurrence of hypospadias.

Finasteride has a similar chemical structure to testosterone and can competitively, selectively and specifically block the activity of type II 5a-proenzyme, inhibit the production of dihydrotestosterone, and thus inhibit the conversion of testosterone into dihydrotestosterone. Some studies have reported that long-term application of finasteride can reduce prostate volume by 20% to 30%, increase urinary flow rate, reduce the severity of clinical symptoms, and improve patients' urethral function. It can also reduce the risk of surgical treatment, enhance clinical efficacy, and reduce the incidence of acute urinary retention. Many studies have pointed out that finasteride has significant efficacy in the clinical treatment of patients with diabetes and prostatic hyperplasia (BPH), and can be used as a safe and effective therapeutic drug commonly used in clinical practice.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.