赛洛多辛(Silodosin)应该怎么服用

With its highly selective antagonism of α1A-adrenergic receptors, silodosin can significantly relieve the lower urinary tract symptoms of benign prostatic hyperplasia. Silodosin is already on the market in the country and has been included in my country's medical insurance.

How to take Silodosin

Standard dosage and frequency of administration

Recommended dosage

1. The recommended dosage for adults is 8 mg once a day.

2. The medicine should be taken at the same time every day to maintain a stable blood concentration.

What to do if you miss a dose

When you forget to take a dose, if it is more than 12 hours before the next dose, you can take it immediately. Otherwise, you should skip the dose and continue the normal medication plan. Do not take a double dose at the same time.

Best time to take silodosin

It is recommended to take silodosin after meals, especially after dinner to improve drug tolerance. Not only can the absorption rate of drugs be improved through a reasonable combination of food, but the incidence of gastrointestinal discomfort can also be reduced.

The pictures are from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

Instructions for taking the tablets

1. Please swallow the tablets whole according to the instructions on the package. Do not chew them or break them in other ways, nor open them and swallow them.

2. Dispense the medicine evenly with an appropriate amount of warm water. You can sit or stand while taking the medicine. Maintaining an upright posture for a certain period of time (generally not less than 30 minutes) after taking the drug can greatly reduce the occurrence of adverse reactions such as dizziness.

Duration of treatment course

It takes 2-4 weeks of continuous medication to gradually show the therapeutic effect of silodosin.

Based on the improvement of specific symptoms in various aspects of the patient and their response to the mid-term treatment, the doctor will make corresponding adjustments or decisions to continue the original treatment plan.

Dose adjustment for special groups

1. Elderly patients usually do not need to adjust the dose.

2. The starting dose for patients with moderate renal impairment should be reduced to 4 mg per day. It is not recommended for patients with severe renal impairment.

3. People with mildly impaired liver function can use conventional doses, while those with moderately or severely damaged liver function should use it with caution.

Principles for dose adjustment

If intolerable side effects occur, the doctor may recommend temporarily reducing the dose or adjusting the medication time. Any dosage adjustments should be made under medical guidance, and patients should not change their medication regimen on their own.

What are the medication precautions for silodosin?

Preoperative medication instructions

Patients who plan to undergo cataract surgery or other eye surgeries are required to inform the surgeon in advance whether they are taking silodosin and other drugs.

Silodosin may cause iris flaccidity syndrome during surgery, so the drug should generally be suspended for 1-2 weeks before surgery.

Prevention of Orthostatic Hypotension

Since the side effects of silodosin can also cause adverse reactions such as dizziness and orthostatic hypotension, you should try to move as slowly as possible when changing positions such as getting up, changing clothes, and walking to avoid aggravation of hypotension caused by sudden changes in position.

Pay special attention when getting up. When jumping up from a lying or sitting position, you should first sit on the edge of the bed or a chair and rest for a while before standing up. Gradually gain a firm footing before getting up to avoid dizziness, dizziness, weakness in limbs and other symptoms caused by sudden getting up.

Drug interaction management

Silodosin may enhance the antihypertensive effect when combined with certain antihypertensive drugs. Caution should be used when coadministering with strong CYP3A4 inhibitors (such as ketoconazole, ritonavir).

Truthfully tell your doctor all the medications you are taking, including those prescribed by your doctor and any over-the-counter medications you purchase.

Precautions for driving and operating machinery

Initial medication may cause a series of discomforts, such as dizziness or temporary blurring of vision. It is recommended to avoid these activities until the individual reaction is clear.

Please check and adjust your physical fitness accordingly first. If you have persistent dizziness and other uncomfortable symptoms, you should go to the hospital for medical treatment in time to avoid causing greater damage to your body due to improper activities.