维贝格龙(Vibegron)会导致哪些副作用

Vibegron is a β3 adrenoceptor agonist used to treat overactive bladder (OAB). It has significant efficacy. However, patients need to fully understand the possible side effects, contraindications and restrictions on the applicable population of Vibegron to avoid affecting their health.

1. What side effects will Vibegeron cause?

Vibegeron is generally well tolerated by patients, but it may still cause mild or severe side effects. The following are the side effects and countermeasures.

1. Headache

When patients have a headache, they can relieve it by resting or taking over-the-counter analgesics such as acetaminophen. At the same time, they should rest more to relieve head fatigue.

2. Urinary tract infection

Patients need to increase the amount of water they drink and keep the urethra clean through urination. If symptoms such as painful urination and hematuria occur, they need to seek medical treatment with antibiotics.

3. Nasopharyngitis and upper respiratory tract infection

Patients can use normal saline to rinse the nasal cavity. If the symptoms are not significantly relieved, they can follow the doctor's advice to take oral antihistamines or antipyretics and analgesia to avoid contact with pollen, cold air and other allergens that may irritate the nasal mucosa.

4. Diarrhea and nausea

Patients need to adjust their diet to ensure light, low-fat, small and frequent meals. For mild diarrhea, oral montmorillonite powder can be taken as directed by the doctor. In severe cases, rehydration is required according to the doctor's advice to avoid water and electrolyte disorders caused by lack of water in diarrhea.

5. Urinary retention

Symptoms include difficulty urinating, bladder distension and pain, etc. It is recommended that the patient stop taking the medication immediately, undergo urinary catheterization to relieve symptoms, and seek medical attention to assess the risk of bladder outlet obstruction.

Most side effects can be effectively controlled through early intervention. If the side effects are not relieved after treatment, it is recommended that the patient stop taking the drug immediately and have the doctor adjust the treatment plan.

2. Other precautions for the use of Vibegroron

In addition to side effects, the following matters need to be paid attention to when using Vibegroron in a standardized manner to minimize the risk of medication.

1. Drug interactions

Vibegron can increase the blood concentration of digoxin. When combined with digoxin, it is necessary to regularly monitor the serum digoxin level and adjust the dose based on the results. The risk of urinary retention may be increased when combined with muscarinic antagonists such as solifenacin. The urinary situation needs to be closely monitored and the medication should be suspended if necessary.

2. Contraindications

It is prohibited to use if you are allergic to Vibegroron or excipients. It is contraindicated in patients with a history of bladder outlet obstruction or urinary retention.

Unopened Vibergaron must be stored at 20°C-25°C. Short-term exposure to 15°C-30°C is allowed. Freezing or high-temperature storage of Vibergaron is prohibited.

3. Which groups of people should pay attention to when using Vibegroron?

There is no sufficient data to confirm the safety of Vibegeron to the fetus. Animal experiments show that the drug components of Vibegeron may enter the placenta. Pregnant women should only use it when the benefits of treatment significantly outweigh the risks, and they need to be supervised by a doctor throughout the entire process. Breastfeeding women should suspend breastfeeding during treatment, or decide after risk assessment under the guidance of a doctor.

Patients with moderate to severe hepatic and renal insufficiency taking Vibegroron may affect drug metabolism. The patient's liver and kidney function and drug tolerance should be closely monitored during medication, and low-dose starting is preferred.