咪达那新片的适应症

Midanacin tablets are a new type of diphenylbutanamide anticholinergic drug, developed and produced by Japan's Kyorin Pharmaceuticals. It is mainly used for overactive bladder. The drug effectively improves symptoms such as urinary urgency, frequency and urinary incontinence by selectively antagonizing muscarinic receptors in bladder smooth muscle. This article will introduce in detail the indications, efficacy, mechanism of action and contraindications of midanacin tablets to help patients and medical workers fully understand this drug.

Indications of Midanacin Tablets

It has a clear scope of clinical application, mainly targeting specific types of urinary system dysfunction.

Overactive Bladder

This drug is specifically designed to treat the urge to urinate, frequent urination, and urge incontinence caused by overactive bladder. Clinical data shows that it can significantly improve patients' daytime urination frequency and nocturia frequency.

Scope of symptom improvement

Applicable to sudden and strong desire to urinate (urgency), increased frequency of urination (frequent urination), and uncontrollable leakage of urine (urge incontinence). These symptoms seriously affect the patient's quality of life, and Midanacin tablets can provide targeted relief.

Correct identification of indications is the prerequisite for ensuring the effectiveness of drug treatment, and patients should use it under the guidance of a professional physician.

Efficacy and role of Midanacin Tablets

Midanacin Tablets exerts therapeutic effects through a unique pharmacological mechanism and has significant clinical advantages.

Mechanism of action

Selectively antagonizes bladder M1 and M3 receptors and inhibits involuntary detrusor contraction. Its high selectivity for bladder tissue (concentration more than 10 times that of serum) reduces systemic side effects.

Clinical efficacy

Midanacin tablets can reduce the number of daily urinations and significantly improve the symptoms of urinary urgency. The bioavailability of 57.8% and the half-life of 3 hours make it suitable for twice daily dosing regimen to maintain stable blood concentration.

Therapeutic Advantages

Compared with traditional anticholinergic drugs, it has low central nervous system penetration and little impact on cognitive function. Clinical studies show that its incidence of side effects such as dry mouth and constipation is significantly lower than similar drugs.

Midanacin tablets provide a highly effective and well-tolerated treatment option for patients with overactive bladder.

Contraindications of Midanacin Tablets

Patients should clarify the contraindications before taking the medicine. The use of Midanacin Tablets should be avoided in the following situations.

Absolute contraindications

It is contraindicated in patients with cognitive dysfunction, as it may aggravate mental symptoms. It is contraindicated in patients with urinary retention and severe gastrointestinal motility disorders, as it may induce urinary obstruction and intestinal obstruction.

Relative contraindications

Patients with glaucoma should use with caution as it may induce acute attacks. Caution is advised in patients with QT prolongation as it may aggravate cardiac arrhythmias. Patients with hepatic and renal insufficiency need to adjust the dose.

Restrictions for special groups

Contraindicated for pregnant women, lactating women and children, lack of safety data. Older adults should start with lower doses and monitor closely for adverse reactions.

Strictly grasping contraindications can avoid serious adverse reactions to the greatest extent and reduce the damage to the body caused by side effects.